Toxicity studies in rats of simple mixtures of chemicals with the same or different target organs

被引：20

作者：

Feron, VJ ^{[1
]}

Groten, JP ^{[1
]}

vanZorge, JA ^{[1
]}

Cassee, FR ^{[1
]}

Jonker, D ^{[1
]}

vanBladeren, PJ ^{[1
]}

机构：

[1] MINIST HOUSING,SPATIAL PLANNING & ENVIRONM,THE HAGUE,NETHERLANDS

来源：

TOXICOLOGY LETTERS | 1995年 / 82-3卷

关键词：

simple mixtures; rats; similar different target organs mode of action;

D O I：

10.1016/0378-4274(95)03580-X

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Mixtures of chemicals with different target organs or the same target organ but different target sites or different modes of action did not appear to be distinctly more hazardous than the individual chemicals, provided the dose level of each chemical in the mixture did not exceed its own 'No-Observed Adverse-Effect Level'. Clearly, for such mixtures and exposure conditions the additivity assumption did not hold. However, the additivity rule appeared to be applicable to mixtures of chemicals with the same target organ and the same mechanism of action or receptor. Fractional 2-factorial study designs were found to be promising tools for examining possible combined actions or interactions of chemicals in a mixture.

引用

页码：505 / 512

页数：8