CHEMOSELECTIVE LIGATION OF MULTIFUNCTIONAL PEPTIDES TO TOPOLOGICAL TEMPLATES VIA THIOETHER FORMATION FOR TASP SYNTHESIS

被引：31

作者：

NEFZI, A ^{[1
]}

SUN, XC ^{[1
]}

MUTTER, M ^{[1
]}

机构：

[1] UNIV LAUSANNE,INST ORGAN CHEM,CH-1015 LAUSANNE,SWITZERLAND

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 02期

关键词：

D O I：

10.1016/0040-4039(94)02230-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Covalent attachment of multifunctional peptides to a topological template containing four maleimide functions was achieved via thioether formation; the resulting TASP (Template Assembled Synthetic Protein) molecules are obtained in high yield and purity.

引用

页码：229 / 230

页数：2

共 11 条

[1]

Creighton T. E., 1984, PROTEINS STRUCTURES, V2nd

[2] CONVENIENT TOTAL SYNTHESIS OF A 4-HELIX TASP MOLECULE BY CHEMOSELECTIVE LIGATION [J].

DAWSON, PE ;

KENT, SBH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (16) :7263-7266

[3]

ERNEST I, 1993, HELV CHIM ACTA, V76, P1539

[4] SERINE DERIVED OXAZOLIDINES AS SECONDARY STRUCTURE DISRUPTING, SOLUBILIZING BUILDING-BLOCKS IN PEPTIDE-SYNTHESIS [J].

HAACK, T ;

MUTTER, M .

TETRAHEDRON LETTERS, 1992, 33 (12) :1589-1592

[5] PREPARATION AND SOME PROPERTIES OF MALEIMIDO ACIDS AND MALEOYL DERIVATIVES OF PEPTIDES [J].

KELLER, O ;

RUDINGER, J .

HELVETICA CHIMICA ACTA, 1975, 58 (02) :531-541

[6]

MORODER L, 1982, PEPTIDES, P667

[7] A CHEMICAL APPROACH TO PROTEIN DESIGN - TEMPLATE-ASSEMBLED SYNTHETIC PROTEINS (TASP) [J].

MUTTER, M ;

VUILLEUMIER, S .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1989, 28 (05) :535-554

[8]

NEFZI A, 1994, PROTEIN PEPTIDE LETT, V0001

[9] THE DENOVO DESIGN OF PROTEIN STRUCTURES [J].

RICHARDSON, JS ;

RICHARDSON, DC .

TRENDS IN BIOCHEMICAL SCIENCES, 1989, 14 (07) :304-309

[10] FACILE SYNTHESIS OF HOMOGENEOUS ARTIFICIAL PROTEINS [J].

ROSE, K .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (01) :30-33

← 1 2 →