ACUTE SODIUM VALPROATE INTOXICATION - OCCURRENCE OF RENAL-FAILURE AND TREATMENT WITH HEMOPERFUSION-HEMODIALYSIS

被引：32

作者：

ROODHOOFT, AM

VANDAM, K

HAENTJENS, D

VERPOOTEN, GA

VANACKER, KJ

机构：

[1] UNIV HOSP ANTWERP,DEPT PAEDIAT,WILRIJKSTRAAT 10,B-2520 ANTWERPEN EDEGEM,BELGIUM

[2] UNIV HOSP ANTWERP,DEPT NEPHROL HYPERTENS,B-2520 ANTWERP,BELGIUM

来源：

EUROPEAN JOURNAL OF PEDIATRICS | 1990年 / 149卷 / 05期

关键词：

Intoxication; Renal failure; Valproate;

D O I：

10.1007/BF02171569

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

In a child who probably received an overdose of sodium valproate, progressive coma, intermittent tonic-clonic seizures and anuria developed. Laboratory investigations revealed coagulopathy, anaemia and mildly disturbed liver function. Progressive renal insufficiency, probably due to rhabdomyolysis and myoglobulinuria, occurred later. Treatment consisted of supportive measures, combined haemoperfusion and haemodialysis and IV thiopentone. Clinical and biochemical normalisation was observed after 11 days. © 1990 Springer-Verlag.

引用

页码：363 / 364

页数：2

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