HIGHLY ENANTIOSELECTIVE SYNTHESIS OF A COREY PROSTAGLANDIN INTERMEDIATE

被引：26

作者：

RONAN, B ^{[1
]}

KAGAN, HB ^{[1
]}

机构：

[1] UNIV PARIS 11,ICMO,SYNTH ASYMETR LAB,CNRS,URA 255,F-91405 ORSAY,FRANCE

来源：

TETRAHEDRON-ASYMMETRY | 1992年 / 3卷 / 01期

关键词：

D O I：

10.1016/S0957-4166(00)82318-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

(R)-p-tolyl vinyl sulfoxide 8 was transformed into the corresponding ethoxysulfonium compound 9 which smoothly underwent reaction with 5-benzyloxymethyl-1,3-cyclopentadiene 2 to give, after basic treatment, the bicyclic sulfoxide 10 with very high de. This compound was transformed in three steps into enantiomerically pure norbornenone 1, a key intermediate in some Corey syntheses of prostaglandins.

引用

页码：115 / 122

页数：8

共 13 条

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