ODD-PAIRED - A ZINC-FINGER PAIR RULE PROTEIN REQUIRED FOR THE TIMELY ACTIVATION OF ENGRAILED AND WINGLESS IN DROSOPHILA EMBRYOS

被引:154
作者
BENEDYK, MJ [1 ]
MULLEN, JR [1 ]
DINARDO, S [1 ]
机构
[1] ROCKEFELLER UNIV, NEW YORK, NY 10021 USA
关键词
DROSOPHILA; PAIR RULE GENES; ZINC FINGER PROTEIN; SEGMENTATION;
D O I
10.1101/gad.8.1.105
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The pair-rule gene, odd-paired (opa), is essential for parasegmental subdivision of the Drosophila embryo. In addition to its previously defined role in the activation of wingless (wg) in odd parasegments, we find that opa is required for the timely activation of wg in the remaining parasegments and for the timely activation of engrailed (en) in all parasegments. opa encodes a zinc finger protein with fingers homologous to those of the Drosophila segment polarity gene ci(D), the human glioblastoma gene GLI and the Caenorhabditis elegans sex determination gene tra-1. Previous work showed that opa activity was essential for the establishment of alternate parasegments, suggesting opa expression or activity would be spatially restricted like other pair-rule genes. Instead, opa mRNA and protein are found throughout all segment primordia. Thus, opa does not act in a spatially restricted manner to establish the position of en and wg expression. Rather, opa must cooperate with other spatially restricted proteins to achieve proper subdivision of the Drosophila embryo.
引用
收藏
页码:105 / 117
页数:13
相关论文
共 80 条
[11]   TEMPORAL AND SPATIAL RELATIONSHIPS BETWEEN SEGMENTATION AND HOMEOTIC GENE-EXPRESSION IN DROSOPHILA EMBRYOS - DISTRIBUTIONS OF THE FUSHI-TARAZU, ENGRAILED, SEX COMBS REDUCED, ANTENNAPEDIA, AND ULTRABITHORAX PROTEINS [J].
CARROLL, SB ;
DINARDO, S ;
OFARRELL, PH ;
WHITE, RAH ;
SCOTT, MP .
GENES & DEVELOPMENT, 1988, 2 (03) :350-360
[12]   EXPRESSION, FUNCTION, AND REGULATION OF THE HAIRY SEGMENTATION PROTEIN IN THE DROSOPHILA EMBRYO [J].
CARROLL, SB ;
LAUGHON, A ;
THALLEY, BS .
GENES & DEVELOPMENT, 1988, 2 (07) :883-890
[13]   LOCALIZATION OF THE FUSHI-TARAZU PROTEIN DURING DROSOPHILA EMBRYOGENESIS [J].
CARROLL, SB ;
SCOTT, MP .
CELL, 1985, 43 (01) :47-57
[15]   MOLECULAR ANALYSIS OF ODD-SKIPPED, A ZINC FINGER ENCODING SEGMENTATION GENE WITH A NOVEL PAIR-RULE EXPRESSION PATTERN [J].
COULTER, DE ;
SWAYKUS, EA ;
BERANKOEHN, MA ;
GOLDBERG, D ;
WIESCHAUS, E ;
SCHEDL, P .
EMBO JOURNAL, 1990, 9 (11) :3795-3804
[16]   SYNERGISTIC ACTIVATION BY THE GLUTAMINE-RICH DOMAINS OF HUMAN TRANSCRIPTION FACTOR SP1 [J].
COUREY, AJ ;
HOLTZMAN, DA ;
JACKSON, SP ;
TJIAN, R .
CELL, 1989, 59 (05) :827-836
[17]   ANALYSIS OF SP1 INVIVO REVEALS MULTIPLE TRANSCRIPTIONAL DOMAINS, INCLUDING A NOVEL GLUTAMINE-RICH ACTIVATION MOTIF [J].
COUREY, AJ ;
TJIAN, R .
CELL, 1988, 55 (05) :887-898
[18]   ESTABLISHMENT AND REFINEMENT OF SEGMENTAL PATTERN IN THE DROSOPHILA EMBRYO - SPATIAL CONTROL OF ENGRAILED EXPRESSION BY PAIR-RULE GENES [J].
DINARDO, S ;
OFARRELL, PH .
GENES & DEVELOPMENT, 1987, 1 (10) :1212-1225
[19]   2-TIERED REGULATION OF SPATIALLY PATTERNED ENGRAILED GENE-EXPRESSION DURING DROSOPHILA EMBRYOGENESIS [J].
DINARDO, S ;
SHER, E ;
HEEMSKERKJONGENS, J ;
KASSIS, JA ;
OFARRELL, PH .
NATURE, 1988, 332 (6165) :604-609
[20]   ALTERATION OF HSP82 GENE-EXPRESSION BY THE GYPSY TRANSPOSON AND SUPPRESSOR GENES IN DROSOPHILA-MELANOGASTER [J].
DORSETT, D ;
VIGLIANTI, GA ;
RUTLEDGE, BJ ;
MESELSON, M .
GENES & DEVELOPMENT, 1989, 3 (04) :454-468