S-100 PROTEIN AND ANNEXIN II2-P11(2) (CALPACTIN-I) ACT IN CONCERT TO REGULATE THE STATE OF ASSEMBLY OF GFAP INTERMEDIATE FILAMENTS IN-VITRO

被引：21

作者：

BIANCHI, R ^{[1
]}

GARBUGLIA, M ^{[1
]}

VERZINI, M ^{[1
]}

GIAMBANCO, I ^{[1
]}

SPRECA, A ^{[1
]}

DONATO, R ^{[1
]}

机构：

[1] UNIV PERUGIA,DEPT EXPTL MED & BIOCHEM SCI,ANAT SECT,I-06126 PERUGIA,ITALY

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 208卷 / 03期

关键词：

D O I：

10.1006/bbrc.1995.1421

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

S-100 protein and annexin II2-p11(2) were reported to inhibit and to stimulate the assembly of glial fibrillary acidic protein (GFAP), respectively, in a Ca2+-dependent manner. Here we show by a number of experimental approaches that S-100 protein contrasts all the effects of annexin II2-p11(2) on GFAP assembly and, conversely, that annexin II2-p11(2) contrasts the inhibitory effects of S-100 protein on GFAP assembly, in a dose-dependent manner in both cases. Altogether, these data suggest that two specific Ca2+ effecters, i.e., annexin II2-p11(2) and S-100 protein, might regulate the state of assembly of glial filaments in a concerted manner. (C) 1995 Academic Press, Inc.

引用

页码：910 / 918

页数：9

共 32 条

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