MODULATION OF MEMORY FIELDS BY DOPAMINE D1 RECEPTORS IN PREFRONTAL CORTEX

被引：1300

作者：

WILLIAMS, GV

GOLDMANRAKIC, PS

机构：

[1] Section of Neurobiology, Yale University School of Medicine, New Haven, CT

来源：

NATURE | 1995年 / 376卷 / 6541期

关键词：

D O I：

10.1038/376572a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Dopamine has been implicated in the cognitive process of working memory but the cellular basis of its action has yet to be revealed. By combining iontophoretic analysis of dopamine receptors with single-cell recording during behaviour, we found that D1 antagonists can selectively potentiate the 'memory fields' of prefrontal neurons which subserve working memory. The precision shown for D1 receptor modulation of mnemonic processing Indicates a direct gating of selective excitatory synaptic inputs to prefrontal neurons during cognition.

引用

页码：572 / 575

页数：4

共 45 条

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