APPROACHES TO NOVEL BICARBOCYCLIC NUCLEOSIDES

被引：10

作者：

CHAO, Q ^{[1
]}

NAIR, V ^{[1
]}

机构：

[1] UNIV IOWA,DEPT CHEM,IOWA CITY,IA 52242

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 41期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0040-4039(95)01545-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Approaches to the synthesis of a novel family of carbocyclic nucleosides of potential anti-HIV interest have been developed. The key carbocyclic intermediate 9 was coupled with desired heterocyclic bases to give the corresponding bicyclic nucleosides. The structure of compound 9 and the bicarbocyclic dideoxynucleosides were confirmed by extensive H-1 and C-13 NMR studies including COSY, NOESY, DEFT and selective INEPT experiments.

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页码：7375 / 7378

页数：4

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