CARBOVIR - THE (-) ENANTIOMER IS A POTENT AND SELECTIVE ANTIVIRAL AGENT AGAINST HUMAN-IMMUNODEFICIENCY-VIRUS INVITRO

被引：49

作者：

COATES, JAV ^{[1
]}

INGGALL, HJ ^{[1
]}

PEARSON, BA ^{[1
]}

PENN, CR ^{[1
]}

STORER, R ^{[1
]}

WILLIAMSON, C ^{[1
]}

CAMERON, JM ^{[1
]}

机构：

[1] GLAXO GRP RES LTD,DEPT MED CHEM 2,GREENFORD UB6 0HE,MIDDX,ENGLAND

来源：

ANTIVIRAL RESEARCH | 1991年 / 15卷 / 02期

关键词：

CARBOVIR; NUCLEOSIDE; HIV; AIDS;

D O I：

10.1016/0166-3542(91)90033-N

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In this paper we describe the in vitro antiviral activity of the (-) enantiomer of carbocyclic 2',3'-deoxydidehydroguanosine, (-) carbovir, a nucleoside analogue that has selective and potent anti-HIV activity in a series of lymphocyte culture systems. The cellular cytotoxicity of this compound has also been evaluated in a number of systems and compared to the saturated dideoxynucleoside analogues AZT and ddC.

引用

页码：161 / 168

页数：8

共 21 条

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