THE SIGNAL MODULATOR PROTEIN-14-3-3 TS A TARGET OF SPHINGOSINE-DEPENDENT OR N,N-DIMETHYLSPHINGOSINE-DEPENDENT KINASE IN 3T3(A31) CELLS

被引：64

作者：

MEGIDISH, T

WHITE, T

TAKIO, K

TITANI, K

IGARASHI, Y

HAKOMORI, S

机构：

[1] BIOMEMBRANE INST,SEATTLE,WA 98119

[2] UNIV WASHINGTON,DEPT PATHOBIOL,SEATTLE,WA 98195

[3] UNIV WASHINGTON,DEPT MICROBIOL,SEATTLE,WA 98195

[4] RIKEN,CTR BIOMOLEC CHARACTERIZAT,WAKO,SAITAMA 35101,JAPAN

[5] FUJITA HLTH UNIV,INST COMPREHENS MED SCI,TOYOAKE,AICHI 47011,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 216卷 / 03期

关键词：

D O I：

10.1006/bbrc.1995.2684

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phosphorylation of a 28 kDa protein in 3T3(A31) cells upon addition of semi-purified kinase was induced only by sphingosine (Sph) or N,N-dimethylsphingosine (DMS), but not by 17 other lipids tested. The 28 kDa protein, a major target of Sph- or DMS-dependent kinase, is now identified as 14-3-3 protein, which modulates a number of key protein kinases involved in regulation of intracellular signaling (Aitken A, Trends Biochem Sci 20:95-97, 1995; Morrison D, Science 266:56-57, 1994). Thus, Sph and DMS modulate the function of a versatile modulator controlling a number of Signaling molecules. (C) 1995 Academic Press, Inc.

引用

页码：739 / 747

页数：9

共 29 条

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