ENHANCEMENT OF MORPHINE-WITHDRAWAL SIGNS IN THE RAT AFTER CHRONIC TREATMENT WITH NALOXONE

被引：11

作者：

SUZUKI, T

FUKAGAWA, Y

MISAWA, M

机构：

[1] Department of Applied Pharmacology, School of Pharmacy, Hoshi University, Shinagawa-ku, Tokyo

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 178卷 / 02期

关键词：

Dependence; Morphine; Naloxone; Paradoxical analgesia; Up-regulation;

D O I：

10.1016/0014-2999(90)90481-K

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Chronic treatment of rats with naloxone for 5 days increased the analgesic threshold (hot plate latency). Further, when rats were treated with morphine-admixed food for 3 days after the chronic naloxone treatment the withdrawal signs precipitated by naloxone were significantly greater in the naloxone-pretreated rats than in saline-pretreated rats. These results suggest that paradoxical analgesia and enhancement of the morphine withdrawal signs induced by chronic naloxone treatment may be associated mainly with up-regulation of μ- and δ-opioid binding sites in the central nervous system. © 1990.

引用

页码：239 / 242

页数：4

共 10 条

[1] OPIATE RECEPTOR SUPERSENSITIVITY PRODUCED BY CHRONIC NALOXONE TREATMENT - DISSOCIATION OF MORPHINE-INDUCED ANTINOCICEPTION AND CONDITIONED TASTE-AVERSION [J].