RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISM OF COMPLEMENT C4 IN JAPANESE PATIENTS WITH RHEUMATOID-ARTHRITIS AND NORMAL JAPANESE

被引：6

作者：

MIMORI, A

TAKEUCHI, F

TOKUNAGA, K

MAEDA, H

MATSUKI, K

MATSUTA, K

NAKANO, K

KOSUGE, E

YUKIYAMA, Y

OMOTO, K

MIYAMOTO, T

机构：

[1] UNIV TOKYO,FAC MED,DEPT MED & PHYS THERAPY,TOKYO 113,JAPAN

[2] UNIV TOKYO,FAC MED,DEPT BLOOD TRANSFUS SERV,TOKYO 113,JAPAN

[3] UNIV TOKYO,FAC SCI,DEPT ANTHROPOL,TOKYO 113,JAPAN

[4] SAITAMA MED SCH,DEPT BLOOD TRANSFUS SERV,MOROYAMA,SAITAMA 35004,JAPAN

来源：

TISSUE ANTIGENS | 1990年 / 35卷 / 05期

关键词：

D O I：

10.1111/j.1399-0039.1990.tb01782.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Abstract: Restriction fragment length polymorphism (RFLP) of the two genes for complement C4A and C4B was studied in 56 Japanese patients with rheumatoid arthritis (RA) and 161 normal individuals. Hindlll digestion revealed six common patterns, from which the segregation of three common RFLP‐types were deduced; 32‐15 kb, 32‐25‐15 kb, and 32‐20‐13‐6.5 kb. The last type showed positive associations with C4B5 and HLA‐DR4. In the RA patients, an increase of this type was found as well as a decrease of the 32‐15 kb/32‐25‐15 kb heterozygotes. Copyright © 1990, Wiley Blackwell. All rights reserved

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页码：197 / 202

页数：6

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