SYNTHESIS AND FUNCTION OF ISOPENTENYL ADENOSINE DERIVATIVES IN TRANSFER-RNA

被引：79

作者：

PERSSON, BC ^{[1
]}

ESBERG, B ^{[1
]}

OLAFSSON, O ^{[1
]}

BJORK, GR ^{[1
]}

机构：

[1] UMEA UNIV,DEPT MICROBIOL,S-90187 UMEA,SWEDEN

来源：

BIOCHIMIE | 1994年 / 76卷 / 12期

关键词：

TRANSFER-RNA MODIFICATION; CYTOKININ; ISOPENTENYL ADENOSINE; METHYLATION; THIOLATION;

D O I：

10.1016/0300-9084(94)90044-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Isopentenyl adenosine derivatives can be found next to the anticodon (position 37) in tRNA from both the Bacteria and Eucarya domains. These modified nucleosides improve the efficiency of tRNA in translation, can increase and decrease translational fidelity, and make the tRNA less codon context sensitive. In bacteria the synthesis of isopentenyl adenosine derivatives seems to be linked to iron metabolism and central metabolic pathways.

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页码：1152 / 1160

页数：9

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