HUMAN THYMOSIN-BETA-4/6-26 GENE IS PART OF A MULTIGENE FAMILY COMPOSED OF 7 MEMBERS LOCATED ON 7 DIFFERENT CHROMOSOMES

被引：22

作者：

CLAUSS, IM ^{[1
]}

WATHELET, MG ^{[1
]}

SZPIRER, J ^{[1
]}

ISLAM, MQ ^{[1
]}

LEVAN, G ^{[1
]}

SZPIRER, C ^{[1
]}

HUEZ, GA ^{[1
]}

机构：

[1] GOTHENBURG UNIV,DEPT GENET,S-40033 GOTHENBURG,SWEDEN

来源：

GENOMICS | 1991年 / 9卷 / 01期

关键词：

D O I：

10.1016/0888-7543(91)90236-8

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have isolated a cDNA encoding the human interferon-inducible gene 6-26, by screening a cDNA library with an oligodeoxynucleotide probe. Its sequence was found to be identical to that of the human thymosin-β4 cDNA, which encodes a protein present in most cell types, but whose function is not clear at present. By hybridization of the thymosin- β4 6-26 cDNA to the DNA of a panel of human-rodent somatic cell hybrids, we found that at least seven genes homologous to this cDNA are present in the human genome. We localized these genes, some of which might be pseudogenes, to seven distinct chromosomes, namely, chromosomes 1, 2, 4, 9, 11, 20, and X. © 1991.

引用

页码：174 / 180

页数：7

共 34 条

[1] CHROMOSOMAL LOCALIZATION OF 2 HUMAN GENES INDUCIBLE BY INTERFERONS, DOUBLE-STRANDED-RNA, AND VIRUSES [J].