NOVEL 7-SUBSTITUTED QUINOLONE ANTIBACTERIAL AGENTS - SYNTHESIS OF 7-ALKENYL, CYCLOALKENYL, AND 1,2,3,6-TETRAHYDRO-4-PYRIDINYL-1,8-NAPHTHYRIDINES

被引：8

作者：

LABORDE, E

KIELY, JS

LESHESKI, LE

SCHROEDER, MC

机构：

[1] Chemistry Department, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, Michigan

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1991年 / 28卷 / 01期

关键词：

D O I：

10.1002/jhet.5570280133

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convergent synthesis of 1,8-naphthyridine antibacterials bearing a carbon-carbon bonded, acyclic or cyclic vinyl substituent at the C-7 position has been achieved. The synthetic methodology is based upon the palladium-catalyzed cross coupling of a 7-chloro-1,8-naphthyridine with an appropriately substituted organotin reagent.

引用

页码：191 / 198

页数：8

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