ISOLATION AND STRUCTURE OF CONSTANOLACTONE-A AND CONSTANOLACTONE-B, NEW CYCLOPROPYL HYDROXYEICOSANOIDS FROM THE TEMPERATE RED ALGA CONSTANTINEA-SIMPLEX

被引：68

作者：

NAGLE, DG ^{[1
]}

GERWICK, WH ^{[1
]}

机构：

[1] OREGON STATE UNIV,COLL PHARM,CORVALLIS,OR 97331

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 21期

关键词：

D O I：

10.1016/S0040-4039(00)89007-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new cyclopropyl and lactone containing eicosanoids, constanolactone A and B, were isolated as synthetic diacetate derivatives from the temperate red alga Constantinea simplex and their structures determined by spectroscopic means. A hydrolysis product of one of these helped to define the lactone size in these new eicosanoids. The co-occurrence of three known 12-lipoxygenase metabolites, 12-S-HETE, 12-S-HEPE, and 12-oxododeca-5(Z), 8(E), 10(E)-trienoic acid, supports a 12-1ipoxygenase origin for the new compounds. © 1990.

引用

页码：2995 / 2998

页数：4

共 19 条

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