DNA CLEAVAGE REACTION OF ANTITUMOR ANTIBIOTIC, KAPURIMYCIN A3, WITH DEOXYTETRANUCLEOTIDE D(CGCG)2

被引：18

作者：

CHAN, KL

SUGIYAMA, H

SAITO, I

HARA, M

机构：

[1] KYOTO UNIV,FAC ENGN,DEPT SYNTHET CHEM,KYOTO 606,JAPAN

[2] KYOWA HAKKO KOGYO CO LTD,TOKYO RES LABS,MACHIDA,TOKYO 194,JAPAN

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 52期

基金：

日本学术振兴会;

关键词：

D O I：

10.1016/0040-4039(91)80574-P

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Kapurimycin A3 (kap A3, 1), an antitumour antibiotic, alkylates N7 of guanine2 (G2) and G4 of d(C1G2C3G4)2 to produce their covalent adducts 2 (64 %) and 3 (7.0 %), respectively. Heating at 90-degrees-C for 5 min degraded both adducts to kap A3 - G adduct (5) with the concurrent release of their respective abasic-site containing oligomers 4 and 6.

引用

页码：7719 / 7722

页数：4

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