A NEW 4-SUBSTITUTED-2-CYCLOHEXENONE SYNTHESIS

被引：6

作者：

BOOKERMILBURN, KI

THOMPSON, DF

机构：

[1] Department of Chemistry, University of Salford, Salford, England

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 45期

关键词：

FERRIC CHLORIDE; RING EXPANSION; CYCLOPROPYL SILYL ETHERS; 4-SUBSTITUTED-2-CYCLOHEXENONES;

D O I：

10.1016/S0040-4039(00)79311-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Conjugate addition of a variety of Grignard reagents to 2-cyclopentenone followed by cyclopropanation of the resulting enol ethers gave a range of substituted cyclopropyl silyl ethers in good yield. Treatment of these cyclopropyl silyl ethers with ferric chloride in DMF gave the one carbon ring expanded beta-chloro ketones which were eliminated to the corresponding 4- substituted-2-cyclohexenones.

引用

页码：7291 / 7294

页数：4

共 10 条

[1] MECHANICAL ACTIVATION OF MAGNESIUM TURNINGS FOR THE PREPARATION OF REACTIVE GRIGNARD-REAGENTS [J].