GROUP-SPECIFIC CYTOLYTIC ANTIBODY DIRECTED AGAINST THE MAJOR GLYCOPROTEIN (GP70) OF MURINE LEUKEMIA VIRUSES IN SERUM OF MICE WITH DORMANT FLV INFECTIONS

被引：8

作者：

CALLAHAN, RM ^{[1
]}

MARX, PA ^{[1
]}

WHEELOCK, EF ^{[1
]}

机构：

[1] THOMAS JEFFERSON UNIV,DEPT MICROBIOL,PHILADELPHIA,PA 19107

来源：

VIROLOGY | 1979年 / 97卷 / 01期

关键词：

D O I：

10.1016/0042-6822(79)90372-6

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Serum of mice with dormant Friend leukemia virus (FLV) infections contains cytolytic activity against FLC-745 cells, a Friend erythroleukemic cell line. FLC-745 cells express only one cell surface FLV-coded antigen, shown by competition radioimmunoassay experiments to be FLV virion gp70. AKR virus blocks completely the cytolytic activity of serum but cannot block the precipitation of gp70 from detergent-disrupted 125I-labeled cells. These results indicate that the FLC-745 cytolytic antibody in serum from mice with dormant FLV infections is directed against virion gp70 and is group specific. Furthermore, this serum contains a type specific gp70 antibody which is not lytic for FLC-745 cells. © 1979.

引用

页码：55 / 67

页数：13

共 47 条

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