GENETIC-MAPPING OF 2 MOUSE HOMEOBOX GENES TLX-1 AND TLX-2 TO MURINE CHROMOSOME-19 AND CHROMOSOME-6

被引：13

作者：

WEN, XY ^{[1
]}

TANG, SJ ^{[1
]}

BREITMAN, ML ^{[1
]}

机构：

[1] UNIV TORONTO,DEPT MOLEC & MED GENET,TORONTO,ON,CANADA

来源：

GENOMICS | 1994年 / 24卷 / 02期

关键词：

D O I：

10.1006/geno.1994.1634

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have previously cloned two mouse homeobox genes Tlx-1 (T-cell leukemia homeobox gene-1) and a related gene Tlx-2 based on their homology to human HOX11, a putative proto oncogene involved in human T-cell leukemia. We have mapped Tlx-1 to mouse chromosome 19 and Tlx-2 to chromosome 6 by linkage analysis using an interspecific backcross (C57BL/6J x Mus spretus) F1 x M. spretus. The proposed gene orders and genetic distances for Tlx-1 and Tlx-2 are centromere 19-Lpc-1-(25.53 cM)-Pltr-4-(5.32 cM)-Tlx-1-(3.19 cM)-Ins-1-(7.45 cM)-Xmv-18, and centromere 6-Tcrb-(12.90 cM)-Mltr-3-(10.75 cM)-Tlx-2-(18.42 cM)-Xmv-6. (C) 1994 Academic Press, Inc.

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页码：388 / 390

页数：3

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