PRIMARY PROGRESSIVE APHASIA WITH FOCAL NEURONAL ACHROMASIA

被引：130

作者：

LIPPA, CF ^{[1
]}

COHEN, R ^{[1
]}

SMITH, TW ^{[1
]}

DRACHMAN, DA ^{[1
]}

机构：

[1] UNIV MASSACHUSETTS,MED CTR,DEPT NEUROPATHOL,WORCESTER,MA 01655

来源：

NEUROLOGY | 1991年 / 41卷 / 06期

关键词：

D O I：

10.1212/WNL.41.6.882

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We describe the clinical, radiologic, neuropsychological, and neuropathologic features of a 69-year-old man with a 3-year history of progressive transcortical expressive aphasia. Neuropsychological testing showed progressive dysfunction of expressive language. Neuropathologic examination demonstrated focal cortical degeneration involving the left superior frontal gyrus, with swollen achromasic neurons and no evidence of Alzheimer's disease, Pick's disease, Creutzfeldt-Jakob disease, Lewy-body disease, or other dementing disorders. This case adds to the known heterogeneity of the underlying pathology of patients with primary progressive aphasia.

引用

页码：882 / 886

页数：5

共 22 条

[1] CORTICAL DEGENERATION WITH SWOLLEN CHROMATOLYTIC NEURONS - ITS RELATIONSHIP TO PICKS DISEASE [J].

CLARK, AW ;

MANZ, HJ ;

WHITE, CL ;

LEHMANN, J ;

MILLER, D ;

COYLE, JT .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1986, 45 (03) :268-284

[2]

CONSTANTINIDIS J, 1985, INTERDISCIPLINARY TO, V19, P72

[3] BALLOONED NEURONS IN SELECT NEURODEGENERATIVE DISEASES CONTAIN PHOSPHORYLATED NEUROFILAMENT EPITOPES [J].

DICKSON, DW ;

YEN, SH ;

SUZUKI, KI ;

DAVIES, P ;

GARCIA, JH ;

HIRANO, A .

ACTA NEUROPATHOLOGICA, 1986, 71 (3-4) :216-223

[4] ANATOMIC BASIS OF TRANSCORTICAL MOTOR APHASIA [J].

FREEDMAN, M ;

ALEXANDER, MP ;

NAESER, MA .

NEUROLOGY, 1984, 34 (04) :409-417

[5] CORTICOBASAL DEGENERATION [J].

GIBB, WRG ;

LUTHERT, PJ ;

MARSDEN, CD .

BRAIN, 1989, 112 :1171-1192

[6] PROGRESSIVE APHASIA IN A PATIENT WITH PICKS DISEASE - A NEUROPSYCHOLOGICAL, RADIOLOGIC, AND ANATOMIC STUDY [J].

GRAFFRADFORD, NR ;

DAMASIO, AR ;

HYMAN, BT ;

HART, MN ;

TRANEL, D ;

DAMASIO, H ;

VANHOESEN, GW ;

REZAI, K .

NEUROLOGY, 1990, 40 (04) :620-626

[7] PROGRESSIVE APHASIA - A PRECURSOR OF GLOBAL DEMENTIA [J].

GREEN, J ;

MORRIS, JC ;

SANDSON, J ;

MCKEEL, DW ;

MILLER, JW .

NEUROLOGY, 1990, 40 (03) :423-429

[8] FOCAL ALZHEIMERS-DISEASE [J].

JAGUST, WJ ;

DAVIES, P ;

TILLERBORCICH, JK ;

REED, BR .

NEUROLOGY, 1990, 40 (01) :14-19

[9] PROGRESSIVE APHASIA WITHOUT DEMENTIA - 2 CASES WITH FOCAL SPONGIFORM DEGENERATION [J].

KIRSHNER, HS ;

TANRIDAG, O ;

THURMAN, L ;

WHETSELL, WO .

ANNALS OF NEUROLOGY, 1987, 22 (04) :527-532

[10] CORTICONIGRAL DEGENERATION WITH NEURONAL ACHROMASIA - A CLINICOPATHOLOGICAL STUDY OF 2 CASES [J].

LIPPA, CF ;

SMITH, TW ;

FONTNEAU, N .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1990, 98 (2-3) :301-310

← 1 2 3 →