EPIDERMAL GROWTH-FACTOR REDUCES RESISTANCE TO DOXORUBICIN

被引：23

作者：

KWOK, TT

SUTHERLAND, RM

机构：

[1] Laboratory of Cell and Molecular Biology, Life Sciences Division, SRI International, Menlo Park, California

来源：

INTERNATIONAL JOURNAL OF CANCER | 1991年 / 49卷 / 01期

关键词：

D O I：

10.1002/ijc.2910490114

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Epidermal growth factor (EGF) increased the sensitivity to doxorubicin (DOX) of a human squamous carcinoma cell line, A431. The relative enhancement of sensitivity by EGF was greater in 2 DOX-resistant sublines, A431/A5 and A431/A10, established by growing cells from surviving colonies after treatment of A431 cells with DOX. A greater number of EGF receptors (both high- and low-affinity binding sites) was found for resistant A431/A5 and A431/A10 cells than for parental cells. The enhanced drug responsiveness is not directly related to EGF effects on growth, as growth inhibition by EGF appears to be similar among the 3 sublines.

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页码：73 / 76

页数：4

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