ELLIPTICINE AND DERIVATIVES INDUCE BREAKAGE OF L1210-CELLS DNA INVITRO

被引：39

作者：

PAOLETTI, C

LESCA, C

CROS, S

MALVY, C

AUCLAIR, C

机构：

[1] Laboratoire de Pharmacologie et de Toxicologie Fondamentales, CNRS, 31078 Toulouse Cedex

来源：

BIOCHEMICAL PHARMACOLOGY | 1979年 / 28卷 / 03期

关键词：

D O I：

10.1016/0006-2952(79)90096-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Part of the radioactive DNA extracted from prelabelled L1210 cells exposed in vitro to ellipticine, 9-hvdroxyellipticine, 2-methyl-9-hydroxyellipticinium and 9-aminoellipticine, migrate more slowly into an alkaline sucrose gradient. These effects occur in less than one hr of exposure, and can be detected at drug concentrations which lie respectively around 1000, 20, 100 and 500 ng per ml whereas the drug concentrations which inhibit by 50 per cent the rate of the in vitro cell growth are 242, 3.9, 13 and 53 ng per ml. The DNA breaks become rapidly undetectable when the cells' exposure to the drugs is discontinued. © 1979.

引用

页码：345 / 350

页数：6

共 26 条

[11] SOME ANTI-TUMOR DERIVATIVES OF ELLIPTICINE DEPRIVED OF MUTAGENIC PROPERTIES [J].