DIMETHYLAMINOETHANOL (DEANOL) - EFFECT ON APOMORPHINE-INDUCED STEREOTYPY AND AN ANIMAL-MODEL OF TARDIVE-DYSKINESIA

被引：2

作者：

DAVIS, KL ^{[1
]}

HOLLISTER, LE ^{[1
]}

VENTO, AL ^{[1
]}

BEILSTEIN, BA ^{[1
]}

ROSEKIND, GR ^{[1
]}

机构：

[1] VET ADM HOSP,PALO ALTO,CA 94304

来源：

PSYCHOPHARMACOLOGY | 1979年 / 63卷 / 02期

关键词：

Apomorphine; Dimethylaminoethanol; Stereotypy; Supersensitivity;

D O I：

10.1007/BF00429692

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Dimethylaminoethanol (DMAE) was administered acutely to rats subsequently injected with apomorphine. A dose of 80 mg of DMAE had no effect on the severity of apomorphine-induced stereotypy. However, 160 mg of DMAE significantly diminished the severity of apomorphine-induced stereotypy. This dose of DMAE did not significantly alter spontaneous locomotor activity. DMAE did not reduce apomorphine-induced stereotypy in animals previously exposed to haloperidol and presumed to have postsynaptic dopamine receptor supersensitivity. These results with DMAE are contrasted with the effects of choline chloride, and suggest that choline chloride may be more effective than DMAE at augmenting striatal cholinergic activity. © 1979 Springer-Verlag.

引用

页码：143 / 146

页数：4

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