ENHANCEMENT OF TONIC AND PHASIC EVENTS OF RAPID EYE-MOVEMENT SLEEP FOLLOWING BILATERAL IBOTENIC ACID INJECTIONS INTO CENTRALIS LATERALIS THALAMIC NUCLEUS OF CATS

被引：9

作者：

MARINI, G ^{[1
]}

GRITTI, I ^{[1
]}

MANCIA, M ^{[1
]}

机构：

[1] CNR,IST FISIOL CENT NERVOSI,I-20131 MILAN,ITALY

来源：

NEUROSCIENCE | 1992年 / 48卷 / 04期

关键词：

D O I：

10.1016/0306-4522(92)90276-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The excitotoxin ibotenic acid (1.2-2.6-mu-l of 50-mu-g/mu-l) was injected bilaterally into the thalamic centralis lateralis nucleus of chronically implanted cats in order to study the effects of tonic excitation followed by destruction of perikarya on the sleep-waking cycle and its electrographic correlates. Ibotenate injections were performed under mild ketamine anaesthesia. Immediately afterward, the animals showed behavioural arousal accompanied first by ocular nystagmiform movements and then by pontogeniculoocipital waves. By 6-10 h post-injection, the number of rapid eye movement sleep episodes, but not their duration, increased compared to the preinjection control period. The injection sites were histologically confirmed using conventional Thionin stains. Additional control was provided by retrograde transport of wheat-germ agglutinin conjugated with horseradish peroxidase. The present results suggest that a population of neurons important for ocular saccades, pontogeniculooccipital waves, and the state of desynchronized sleep is present in the internal medullary lamina, in particular in the centralis lateralis nuclei.

引用

页码：877 / 888

页数：12

共 42 条

[11] EPIDURAL KAINATE, BUT NOT IBOTENATE, PRODUCES - LESIONS IN LOCAL AND DISTANT REGIONS OF THE BRAIN A COMPARISON OF THE INTRA-CEREBRAL ACTIONS OF KAINIC ACID AND IBOTENIC ACID [J].