BRAIN PHOSPHORUS-METABOLISM IN DEPRESSIVE-DISORDERS DETECTED BY P-31 MAGNETIC-RESONANCE SPECTROSCOPY

被引：139

作者：

KATO, T ^{[1
]}

TAKAHASHI, S ^{[1
]}

SHIOIRI, T ^{[1
]}

INUBUSHI, T ^{[1
]}

机构：

[1] SHIGA UNIV MED SCI, MOLEC NEUROBIOL RES CTR, OTSU, SHIGA 52021, JAPAN

来源：

JOURNAL OF AFFECTIVE DISORDERS | 1992年 / 26卷 / 04期

关键词：

BIPOLAR DISORDER; DEPRESSION; MAGNETIC RESONANCE SPECTROSCOPY; INTRACELLULAR PH; PHOSPHOCREATINE; PHOSPHOMONOESTER;

D O I：

10.1016/0165-0327(92)90099-R

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Brain phosphorus metabolism was measured in 22 patients with depressive disorders. Ten of them had DSM-III-R bipolar disorder, and 12 had major depression. In bipolar patients, phosphomonoester (PME) and intracellular pH were significantly increased in the depressive state than in the euthymic state, while those values in the euthymic state were significantly low as compared to age-matched normal controls. Phosphocreatine (PCr) was significantly decreased in severely depressed patients compared to mild depressives. These findings suggest that high energy phosphate metabolism, intracellular pH and membrane phospholipid metabolism are altered in depressive disorders.

引用

页码：223 / 230

页数：8

共 29 条

[1] LOW BRAIN UPTAKE OF L-[C-11]5-HYDROXYTRYPTOPHAN IN MAJOR DEPRESSION - A POSITRON EMISSION TOMOGRAPHY STUDY ON PATIENTS AND HEALTHY-VOLUNTEERS [J].

AGREN, H ;

REIBRING, L ;

HARTVIG, P ;

TEDROFF, J ;

BJURLING, P ;

HORNFELDT, K ;

ANDERSSON, Y ;

LUNDQVIST, H ;

LANGSTROM, B .

ACTA PSYCHIATRICA SCANDINAVICA, 1991, 83 (06) :449-455

[2]

BAXTER LR, 1989, ARCH GEN PSYCHIAT, V46, P243

[3] CHRONIC LI+ ATTENUATES AGONIST-MEDIATED AND PHORBOL ESTER-MEDIATED NA+/H+ ANTIPORTER ACTIVITY IN HL-60 CELLS [J].

BITRAN, JA ;

POTTER, WZ ;

MANJI, HK ;

GUSOVSKY, F .

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION, 1990, 188 (4-5) :193-202

[4] DEPTH-RESOLVED SURFACE-COIL SPECTROSCOPY (DRESS) FOR INVIVO H-1, P-31, AND C-13 NMR [J].

BOTTOMLEY, PA ;

FOSTER, TB ;

DARROW, RD .

JOURNAL OF MAGNETIC RESONANCE, 1984, 59 (02) :338-342

[5]

BRENTON DP, 1985, LANCET, V1, P115

[6] INVIVO P-31 NMR PROFILES OF ALZHEIMERS-DISEASE AND MULTIPLE SUBCORTICAL INFARCT DEMENTIA [J].

BROWN, GG ;

LEVINE, SR ;

GORELL, JM ;

PETTEGREW, JW ;

GDOWSKI, JW ;

BUERI, JA ;

HELPERN, JA ;

WELCH, KMA .

NEUROLOGY, 1989, 39 (11) :1423-1427

[7] FRONTAL-CORTEX AND BASAL GANGLIA METABOLIC RATES ASSESSED BY POSITRON EMISSION TOMOGRAPHY WITH [F-18] 2-DEOXYGLUCOSE IN AFFECTIVE-ILLNESS [J].

BUCHSBAUM, MS ;

WU, J ;

DELISI, LE ;

HOLCOMB, H ;

KESSLER, R ;

JOHNSON, J ;

KING, AC ;

HAZLETT, E ;

LANGSTON, K ;

POST, RM .

JOURNAL OF AFFECTIVE DISORDERS, 1986, 10 (02) :137-152

[8] RESOLUTION ENHANCEMENT OF PROTEIN PMR SPECTRA USING DIFFERENCE BETWEEN A BROADENED AND A NORMAL SPECTRUM [J].

CAMPBELL, ID ;

DOBSON, CM ;

WILLIAMS, RJP ;

XAVIER, AV .

JOURNAL OF MAGNETIC RESONANCE, 1973, 11 (02) :172-181

[9] PHOSPHORYLETHANOLAMINE - THE MAJOR CONSTITUENT OF THE PHOSPHOMONOESTER PEAK OBSERVED BY P-31-NMR ON DEVELOPING DOG BRAIN [J].

GYULAI, L ;

BOLINGER, L ;

LEIGH, JS ;

BARLOW, C ;

CHANCE, B .

FEBS LETTERS, 1984, 178 (01) :137-142

[10]

HUBESCH B, 1990, 31P MAGNETIC RESONAN, P995

← 1 2 3 →