DIAGNOSTIC ULTRASOUND - EFFECTS ON THE DNA AND GROWTH-PATTERNS OF ANIMAL-CELLS

被引：81

作者：

LIEBESKIND, D ^{[1
]}

BASES, R ^{[1
]}

ELEQUIN, F ^{[1
]}

NEUBORT, S ^{[1
]}

LEIFER, R ^{[1
]}

GOLDBERG, R ^{[1
]}

KOENIGSBERG, M ^{[1
]}

机构：

[1] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT RADIOL,BRONX,NY 10461

来源：

RADIOLOGY | 1979年 / 131卷 / 01期

关键词：

D O I：

10.1148/131.1.177

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The effects of diagnostic levels of ultrasound on DNA of Hela cells included: increased immunoreactivity to antinucleoside antibodies in g1 cells, strongly suggestive of unwinding of the helix or singe-strand break induction, and low levels of non-semiconservative synthesis in logarithmically growing cells treated with hydroxyurea, indicating repair synthesis. In the C3H mouse cell line 10T-1/2, Cl 8, loss of contact inhibition with a criss-crossed growth pattern was seen. In one experiment, tumors developed in syngeneic mice at the site of infection of ultrasonically treated cells. Ultrasound in the diagnostic range appears to cause detectable effects on DNA and growth patterns of animal cells.

引用

页码：177 / 184

页数：8

共 38 条

[21]

LIEBESKIND D, 1977, CANCER RES, V37, P323

[22] SELECTIVE INHIBITION OF TRANSFORMED CELLS IN CULTURE BY ANTI-THYMIDINE ANTIBODIES [J].

LIEBESKIND, DS ;

HSU, KC ;

ERLANGER, BF ;

BEISER, SM .

NATURE-NEW BIOLOGY, 1971, 234 (47) :127-+

[23]

LIEBESKIND DS, 1974, SCI P AM ASS CANCER, V15, P110

[24] ULTRASOUND AND CHROMOSOME DAMAGE [J].

LOOBY, P ;

FLEMING, JEE .

BRITISH JOURNAL OF RADIOLOGY, 1972, 45 (533) :335-&

[25] INVESTIGATION INTO POSSIBLE GENETIC HAZARDS OF ULTRASOUND [J].

LYON, MF ;

SIMPSON, GM .

BRITISH JOURNAL OF RADIOLOGY, 1974, 47 (562) :712-722

[26] CHROMOSOME ABERRATIONS INDUCED BY AN ULTRASONIC FETAL PULSE DETECTOR [J].

MACINTOS.IJ ;

DAVEY, DA .

BRITISH MEDICAL JOURNAL, 1970, 4 (5727) :92-&

[27] RELATIONSHIP BETWEEN INTENSITY OF ULTRASOUND AND INDUCTION OF CHROMOSOME ABERRATIONS [J].

MACINTOSH, IJ ;

DAVEY, DA .

BRITISH JOURNAL OF RADIOLOGY, 1972, 45 (533) :320-+

[28]

MACINTOSH IJC, 1974, C ULTRASOUND BIOEFFE

[29]

MILLER M W, 1976, Journal of Clinical Ultrasound, V4, P169, DOI 10.1002/jcu.1870040304

[30] TRANSFORMATION OF C3H-10T1-2 CL8 MOUSE EMBRYO FIBROBLASTS BY ULTRAVIOLET-IRRADIATION AND A PHORBOL ESTER [J].

MONDAL, S ;

HEIDELBERGER, C .

NATURE, 1976, 260 (5553) :710-711

← 1 2 3 4 →