DOSE-RESPONSE FOR HERITABLE TRANSLOCATIONS INDUCED BY ACRYLAMIDE IN SPERMATIDS OF MICE

被引：36

作者：

ADLER, ID ^{[1
]}

REITMEIR, P ^{[1
]}

SCHMOLLER, R ^{[1
]}

SCHRIEVERSCHWEMMER, G ^{[1
]}

机构：

[1] GSF FORSCHUNGSZENTRUM UNWELT & GESUNDHEIT GMBH,INST MED INFORMAT & SYSTEM FORSCH,D-85758 OBERSCHLEISSHEIM,GERMANY

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 1994年 / 309卷 / 02期

关键词：

ACRYLAMIDE; HERITABLE TRANSLOCATIONS; MOUSE SPERMATIDS;

D O I：

10.1016/0027-5107(94)90103-1

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A heritable translocation test was carried out with acrylamide (AA) to obtain a dose-response relationship for induction of reciprocal translocations in late spermatids of the mouse. Male C3H/El mice were treated with single i.p. doses of 50 and 100 mg/kg of acrylamide and mated 7-16 days after treatment to untreated female 102/El mice. Translocation carriers among the F-1 progeny were selected by a sequential procedure of fertility testing and cytogenetic analysis including G-band karyotyping to determine the chromosomes involved in the respective translocations. The translocation frequencies observed with 50 mg/kg and 100 mg/kg of AA were 0.6% and 2.7%, respectively. The historical control translocation frequency was 0.04%. Doubling dose estimates based on these and previous data are discussed.

引用

页码：285 / 291

页数：7

共 26 条

[11] CHRONIC TOXICITY AND ONCOGENICITY STUDY ON ACRYLAMIDE INCORPORATED IN THE DRINKING-WATER OF FISCHER 344 RATS [J].