EVENT-RELATED BRAIN POTENTIAL EVIDENCE FOR A VERBAL WORKING-MEMORY DEFICIT IN MULTIPLE-SCLEROSIS

被引:82
作者
RUCHKIN, DS
GRAFMAN, J
KRAUSS, GL
JOHNSON, R
CANOUNE, H
RITTER, W
机构
[1] JOHNS HOPKINS UNIV HOSP, DEPT NEUROL, BALTIMORE, MD USA
[2] NINCDS, MED NEUROL BRANCH, COGNIT NEUROSCI SECT, BETHESDA, MD 20892 USA
[3] CUNY QUEENS COLL, DEPT PSYCHOL, FLUSHING, NY 11367 USA
[4] CUNY, LEHMAN COLL, DEPT PSYCHOL, NEW YORK, NY 10021 USA
[5] ALBERT EINSTEIN COLL MED, DEPT NEUROSCI, NEW YORK, NY USA
关键词
MULTIPLE SCLEROSIS; WORKING MEMORY; PHONOLOGICAL LOOP; EVENT-RELATED POTENTIALS; LEFT ANTERIOR NEGATIVITY;
D O I
10.1093/brain/117.2.289
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Memory deficits are frequently identified in patients with multiple sclerosis. Both working (short-term) and long-term memory appear affected, particularly on free-recall tasks. The focus of our study was to examine neurophysiological correlates of working memory processes and to identify the specific components responsible for the working memory deficits reported in multiple sclerosis. Event-related brain potentials (ERPs) were recorded from the scalp of mildly afflicted multiple sclerosis patients and their matched normal controls during the performance of phonological and visuo-spatial working memory tasks. Neuropsychological test, behavioural performance and ERP data all indicated that verbal working memory is especially susceptible to impairment by multiple sclerosis, while visuospatial working memory is less susceptible. The pattern of results further indicated that the verbal working memory dysfunction in multiple sclerosis is at least partially due to impairment in the phonological loop, a rehearsal mechanism for retaining verbal information in working memory.
引用
收藏
页码:289 / 305
页数:17
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