SYNTHESIS AND BIOLOGICAL PROPERTIES OF CARBA-ANALOGS OF HEAT-STABLE ENTEROTOXIN (ST) PRODUCED BY ENTEROTOXIGENIC ESCHERICHIA-COLI

被引：4

作者：

HIDAKA, Y

OHMORI, K

WADA, A

OZAKI, H

ITO, H

HIRAYAMA, T

TAKEDA, Y

SHIMONISHI, Y

机构：

[1] OSAKA UNIV,INST PROT RES,YAMADAOKA 3-2,SUITA,OSAKA 565,JAPAN

[2] KYOTO UNIV,FAC MED,SAKYO KU,KYOTO 606,JAPAN

[3] UNIV TOKYO,INST MED SCI,TOKYO 108,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 176卷 / 03期

关键词：

D O I：

10.1016/0006-291X(91)90375-H

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Analogs of a heat-stable enterotoxin (ST) that have a CH2-S linkage instead of an S-S linkage in the molecule were synthesized by conventional methods. The synthetic peptides showed toxicity, assayed as induction of fluid secretion in suckling mice, although their toxicities were hundredth that of native ST. This finding implies that ST is not recognized by its receptor protein through an exchange reaction between its disulfide linkages and thiol-groups of its receptor proteins(s), but through hydrophobic or electrostatic interactions. © 1991.

引用

页码：958 / 965

页数：8

共 23 条

[1] AMINO-ACID-SEQUENCE OF A HEAT-STABLE ENTERO-TOXIN PRODUCED BY HUMAN ENTERO-TOXIGENIC ESCHERICHIA-COLI [J].