REPEATED D-1 RECEPTOR AGONIST TREATMENT BLOCKS COCAINE-INDUCED LOCOMOTOR-ACTIVITY AND C-FOS EXPRESSION

被引：17

作者：

ASIN, KE ^{[1
]}

NIKKEL, AL ^{[1
]}

WIRTSHAFTER, D ^{[1
]}

机构：

[1] UNIV ILLINOIS,DEPT PSYCHOL,CHICAGO,IL 60680

来源：

BRAIN RESEARCH | 1994年 / 637卷 / 1-2期

关键词：

COCAINE; DOPAMINE D-1 RECEPTOR; C-FOS GENE EXPRESSION; SUBSENSITIVITY; A-77636;

D O I：

10.1016/0006-8993(94)91258-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Pretreatment of rats for 4 days with the selective dopamine D, receptor agonist A-77636 attenuated the ability of cocaine to induce locomotor hyperactivity and to stimulate the expression of the proto-oncogene c-fos in the striatum and nucleus accumbens. Our results suggest that repeated D-1 agonist treatment leads to subsensitivity of D-1 receptors involved in mediating some of the effects of cocaine on behavior and gene expression.

引用

页码：342 / 344

页数：3

共 14 条

[1] EFFECTS OF REPEATED DOPAMINE-D(1) RECEPTOR STIMULATION ON ROTATION AND C-FOS EXPRESSION
ASIN, KE
WIRTSHAFTER, D
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1993, 235 (01) : 167 - 168
[2] BHAT RV, 1992, J PSYCHIATR NEUROSCI, V17, P94
[3] D1 AND D2 RECEPTOR ANTAGONISTS DIFFERENTLY AFFECT COCAINE-INDUCED LOCOMOTOR HYPERACTIVITY IN THE MOUSE
CABIB, S
CASTELLANO, C
CESTARI, V
FILIBECK, U
PUGLISIALLEGRA, S
[J]. PSYCHOPHARMACOLOGY, 1991, 105 (03) : 335 - 339
[4] AMPHETAMINE AND COCAINE INDUCE DRUG-SPECIFIC ACTIVATION OF THE C-FOS GENE IN STRIOSOME MATRIX COMPARTMENTS AND LIMBIC SUBDIVISIONS OF THE STRIATUM
GRAYBIEL, AM
MORATALLA, R
ROBERTSON, HA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (17) : 6912 - 6916
[5] HENRY DJ, 1991, J PHARMACOL EXP THER, V258, P882
[6] REGULATION OF IMMEDIATE EARLY GENE-EXPRESSION AND AP-1 BINDING IN THE RAT NUCLEUS-ACCUMBENS BY CHRONIC COCAINE
HOPE, B
KOSOFSKY, B
HYMAN, SE
NESTLER, EJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (13) : 5764 - 5768
[7] COCAINE RELEASES LIMBIC ACETYLCHOLINE THROUGH ENDOGENOUS DOPAMINE ACTION ON D1 RECEPTORS
IMPERATO, A
OBINU, MC
DEMONTIS, MV
GESSA, GL
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1992, 229 (2-3) : 265 - 267
[8] KATZ JL, 1993, J PHARMACOL EXP THER, V264, P183
[9] SELECTIVE EFFECTS OF THE D1 DOPAMINE RECEPTOR AGONIST, SKF-38393, ON BEHAVIOR MAINTAINED BY COCAINE INJECTION IN SQUIRREL-MONKEYS
KATZ, JL
WITKIN, JM
[J]. PSYCHOPHARMACOLOGY, 1992, 109 (1-2) : 241 - 244
[10] EFFECTS OF REPEATED INJECTIONS OF COCAINE ON D1 AND D2 DOPAMINE-RECEPTORS IN RAT-BRAIN
KLEVEN, MS
PERRY, BD
WOOLVERTON, WL
SEIDEN, LS
[J]. BRAIN RESEARCH, 1990, 532 (1-2) : 265 - 270

← 1 2 →