STEREOSELECTIVE SYNTHESIS OF NOVEL ANALOGS OF 2'DEOXYNUCLEOSIDES AND 2',3'-DIDEOXYNUCLEOSIDES WITH POTENTIAL ANTIVIRAL ACTIVITY

被引：27

作者：

CICERO, DO

NEUNER, PJS

FRANZESE, O

DONOFRIO, C

IRIBARREN, AM

机构：

[1] IST RIC BIOL MOLEC P ANGELETTI,I-00040 ROME,ITALY

[2] UNIV ROMA TOR VERGATA,DEPT EXPTL MED & BIOCHEM SCI,I-00173 ROME,ITALY

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(01)80252-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The stereoselective synthesis of new 2'-deoxy- and 2',3'-dideoxy-2'-C-alkylnucleosides with potential antiviral activity is presented. The compounds here described were tested for their antiproliferative property against human tumor cell lines and none showed any significant antitumor activity.

引用

页码：861 / 866

页数：6

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