EFFECT OF ALFALFA MEAL ON SHRINKAGE (REGRESSION) OF ATHEROSCLEROTIC PLAQUES DURING CHOLESTEROL FEEDING IN MONKEYS

被引：75

作者：

MALINOW, MR ^{[1
]}

MCLAUGHLIN, P ^{[1
]}

NAITO, HK ^{[1
]}

LEWIS, LA ^{[1
]}

MCNULTY, WP ^{[1
]}

机构：

[1] CLEVELAND CLIN EDUC FDN, CLEVELAND, OH 44106 USA

来源：

ATHEROSCLEROSIS | 1978年 / 30卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Aorticatherosclerosis; Coronary atherosclerosis; Intestinal absorption; Phospholipids; Plasma cholesterol; Saponins; Triglycerides;

D O I：

10.1016/0021-9150(78)90150-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A semipurified diet containing 1.2 mg of cholesterol/Cal was fed to cynomolgus monkeys (Macaca fascicularis). At the end of 6 months, a group of 18 animals was killed for evaluation of atherosclerosis in the aorta and the coronary arteries. The remaining monkeys were assigned to three groups of 18 animals each and were fed, during the following 18 months, semipurified diets containing 0.34 mg of cholesterol/Cal with or without alfalfa meal, or a diet consisting entirely of Monkey Chow. A decrease in cholesterolemia and plasma phospholipid levels, normalization in the distribution of plasma lipoproteins, and reduction in the extent of aortic and coronary atherosclerosis were observed in monkeys fed the semipurified diet containing alfalfa, although the intake of cholesterol remained as high as in the usual American diet. These changes, also observed in monkeys fed a chow diet almost devoid of cholesterol, suggest that alfalfa counteracts the atherogenic effect of dietary cholesterol. © 1978.

引用

页码：27 / 43

页数：17

共 59 条

[31]

MALINOW MR, 1977, STEROIDS, V29, P105, DOI 10.1016/0039-128X(77)90113-1

[32]

MALINOW MR, 1976, CLIN RES, V24, pA86

[33] EFFECTS OF PYRIDINOLCARBAMATE ON INDUCED ATHEROSCLEROSIS IN CYNOMOLGUS MONKEYS (MACACA-IRA) [J].