IDENTIFICATION OF A CIS-ACTING POSITIVE REGULATORY ELEMENT OF THE GLIAL FIBRILLARY ACIDIC PROTEIN GENE

被引:46
作者
SARID, J
机构
[1] Division of Neurosurgery, Department of Surgery Brigham and Women's Hospital, Harvard Medical School, Boston
关键词
GFAP GENE; GLIOBLASTS; ASTROCYTES;
D O I
10.1002/jnr.490280209
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Development regulation of astrocyte-specific expression of the glial fibrillary acidic protein (GFAP) gene reflects transition of immature glioblasts to mature astrocytes. Described here is the cloning and sequencing of the 5'-flanking region of the mouse GFAP gene. It contains a glial-specific positive cis-acting regulatory element that directs preferential expression of a linked reporter gene when transfected into GFAP-positive glioblastoma cells. Sequence analysis of this region revealed the presence of a putative AP-1 binding site, implying a possible role for AP-1 factors in the astroglial-specific expression of the GFAP gene.
引用
收藏
页码:217 / 228
页数:12
相关论文
共 46 条
[11]  
DAHL D, 1981, EUR J CELL BIOL, V24, P191
[12]  
DANNENBERG AM, 1981, METHODS STUDYING MON, P375
[13]  
Fedoroff S., 1986, ASTROCYTES
[14]   POWERFUL AND VERSATILE ENHANCER-PROMOTER UNIT FOR MAMMALIAN EXPRESSION VECTORS [J].
FOECKING, MK ;
HOFSTETTER, H .
GENE, 1986, 45 (01) :101-105
[15]   RIBONUCLEIC-ACID ISOLATED BY CESIUM-CHLORIDE CENTRIFUGATION [J].
GLISIN, V ;
CRKVENJAKOV, R ;
BYUS, C .
BIOCHEMISTRY, 1974, 13 (12) :2633-2637
[16]   NEW TECHNIQUE FOR ASSAY OF INFECTIVITY OF HUMAN ADENOVIRUS 5 DNA [J].
GRAHAM, FL ;
VANDEREB, AJ .
VIROLOGY, 1973, 52 (02) :456-467
[17]   C-JUN DIMERIZES WITH ITSELF AND WITH C-FOS, FORMING COMPLEXES OF DIFFERENT DNA-BINDING AFFINITIES [J].
HALAZONETIS, TD ;
GEORGOPOULOS, K ;
GREENBERG, ME ;
LEDER, P .
CELL, 1988, 55 (05) :917-924
[18]   TRANSCRIPTION FACTOR AP-2 MEDIATES INDUCTION BY 2 DIFFERENT SIGNAL-TRANSDUCTION PATHWAYS - PROTEIN-KINASE-C AND CAMP [J].
IMAGAWA, M ;
CHIU, R ;
KARIN, M .
CELL, 1987, 51 (02) :251-260
[19]   TRANSCRIPTIONAL REGULATION BY DIMERIZATION - 2 SIDES TO AN INCESTUOUS RELATIONSHIP [J].
JONES, N .
CELL, 1990, 61 (01) :9-11
[20]   TRANS-ACTING PROTEIN FACTORS AND THE REGULATION OF EUKARYOTIC TRANSCRIPTION - LESSONS FROM STUDIES ON DNA TUMOR-VIRUSES [J].
JONES, NC ;
RIGBY, PWJ ;
ZIFF, EB .
GENES & DEVELOPMENT, 1988, 2 (03) :267-281