A SURPRISING OBSERVATION ABOUT MITSUNOBU REACTIONS IN SOLID-PHASE SYNTHESIS

被引：69

作者：

RICHTER, LS ^{[1
]}

GADEK, TR ^{[1
]}

机构：

[1] GENENTECH INC,DEPT BIOORGAN CHEM,S SAN FRANCISCO,CA 94080

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 27期

关键词：

D O I：

10.1016/S0040-4039(00)76946-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Mitsunobu reaction of N-Boc-L-Tyrosine methyl eater with hydroxymethyl polystyrene resin proceeds in practically quantitative yield in the presence of a tertiary amine. Coupling yields in the absence of an amine are significantly lower.

引用

页码：4705 / 4706

页数：2

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