IRON AND BACTERIAL VIRULENCE - A BRIEF OVERVIEW

被引：71

作者：

GRIFFITHS, E

机构：

[1] National Institute for Biological Standards and Control, Hertfordshire, South Mimms, Potters Bar

来源：

BIOLOGY OF METALS | 1991年 / 4卷 / 01期

关键词：

IRON AVAILABILITY; MICROBIAL PATHOGENICITY; IRON-UPTAKE SYSTEM; HEME;

D O I：

10.1007/BF01135551

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Iron is now recognized as playing a vital role in infection. Not only does its restricted availability in tissue fluids present microbial pathogens with the problem of acquiring sufficient for multiplication in vivo, but it also constitutes a major environmental signal which co-ordinately regulates the expression of a number of virulence and metabolic genes. Progress in understanding the strategies used by pathogens for acquiring iron in vivo, and their responses to iron restriction, is providing a fresh insight into microbial pathogenicity. © 1991 Springer-Verlag.

引用

页码：7 / 13

页数：7

共 83 条

[31] FERNANDEZBEROS ME, 1988, FEMS MICROBIOL LETT, V49, P397
[32] EVIDENCE FOR DIRECT REGULATION OF DIPHTHERIA-TOXIN GENE-TRANSCRIPTION BY AN FE-2+ DEPENDENT DNA-BINDING REPRESSOR, DTOXR, IN CORYNEBACTERIUM-DIPHTHERIAE
FOUREL, G
PHALIPON, A
KACZOREK, M
[J]. INFECTION AND IMMUNITY, 1989, 57 (10) : 3221 - 3225
[33] DIFFERENTIAL REGULATION BY IRON OF REGA AND TOXA TRANSCRIPT ACCUMULATION IN PSEUDOMONAS-AERUGINOSA
FRANK, DW
STOREY, DG
HINDAHL, MS
IGLEWSKI, BH
[J]. JOURNAL OF BACTERIOLOGY, 1989, 171 (10) : 5304 - 5313
[34] IDENTIFICATION OF AN IRON-REGULATED VIRULENCE DETERMINANT IN VIBRIO-CHOLERAE, USING TNPHOA MUTAGENESIS
GOLDBERG, MB
DIRITA, VJ
CALDERWOOD, SB
[J]. INFECTION AND IMMUNITY, 1990, 58 (01) : 55 - 60
[35] THE REGULATION OF BACTERIAL VIRULENCE GENES BY ENVIRONMENTAL SIGNALS
GRIFFITHS, E
[J]. CURRENT OPINION IN INFECTIOUS DISEASES, 1989, 2 (06) : 819 - 826
[36] ANTIGENIC AND MOLECULAR HETEROGENEITY OF THE TRANSFERRIN-BINDING PROTEIN OF NEISSERIA-MENINGITIDIS
GRIFFITHS, E
STEVENSON, P
RAY, A
[J]. FEMS MICROBIOLOGY LETTERS, 1990, 69 (1-2) : 31 - 36
[37] NATURALLY-OCCURRING ANTIBODIES IN HUMAN-SERA THAT REACT WITH THE IRON-REGULATED OUTER-MEMBRANE PROTEINS OF ESCHERICHIA-COLI
GRIFFITHS, E
STEVENSON, P
THORPE, R
CHART, H
[J]. INFECTION AND IMMUNITY, 1985, 47 (03) : 808 - 813
[38] MECHANISM FOR IRON-REGULATED TRANSCRIPTION OF THE ESCHERICHIA-COLI CIR GENE - METAL-DEPENDENT BINDING OF FUR PROTEIN TO THE PROMOTERS
GRIGGS, DW
KONISKY, J
[J]. JOURNAL OF BACTERIOLOGY, 1989, 171 (02) : 1048 - 1054
[39] ROLE OF HEME COMPOUNDS AND HAPTOGLOBIN IN VIBRIO-VULNIFICUS PATHOGENICITY
HELMS, SD
OLIVER, JD
TRAVIS, JC
[J]. INFECTION AND IMMUNITY, 1984, 45 (02) : 345 - 349
[40] THE PILI OF AEROMONAS-HYDROPHILA - IDENTIFICATION OF AN ENVIRONMENTALLY REGULATED MINI PILIN
HO, ASY
MIETZNER, TA
SMITH, AJ
SCHOOLNIK, GK
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 172 (03) : 795 - 806

← 1 2 3 4 5 6 7 8 9 →