REACTIVATION OF METAL-REQUIRING APOENZYMES BY PHYTOCHELATIN METAL-COMPLEXES

被引：48

作者：

THUMANN, J

GRILL, E

WINNACKER, EL

ZENK, MH

机构：

[1] UNIV MUNICH,LEHRSTUHL PHARMAZEUT BIOL,KARLSTR 29,W-8000 MUNICH 2,GERMANY

[2] UNIV MUNICH,GENZENTRUM,W-8033 MARTINSRIED,GERMANY

来源：

FEBS LETTERS | 1991年 / 284卷 / 01期

关键词：

METALLO-ENZYME; PHYTOCHELATIN; METAL TRANSFER; REACTIVATION; HOMEOSTASIS;

D O I：

10.1016/0014-5793(91)80763-S

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The enzymatically inactive, metal-requiring apoforms of diamino oxidase and of carbonic anhydrase were reactivated by copper- and zinc-phytochelatin complexes, respectively. The level and the rate of reactivation effected by metal complexes consisting of poly(gamma-glutamylcysteinyl)glycine as well as by the respective free metal ion were compared. An efficient transfer of zinc and copper from phytochelatin-complexes to apoenzymes was observed in vitro.

引用

页码：66 / 69

页数：4

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