CONVULSIVE EFFECTS OF 3-AMINOPYRIDINE ON CORTICAL-NEURONS

被引：32

作者：

BARANYI, A

FEHER, O

机构：

[1] Department of Comparative Physiology, 6701 Szeged

来源：

ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY | 1979年 / 47卷 / 06期

关键词：

D O I：

10.1016/0013-4694(79)90303-1

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The authors examined the effects of 3-aminopyridine (3-AP) on pyramidal tract neurones in the motor cortex of anesthetised cats. 3-AP proved to be a strong convulsive agent. Local application of 3-AP in concentrations of 15-20 mM resulted in typical paroxysmal alterations of neuronal activity: (a) enhancement of background firing, (b) augmentation of EPSPs, (c) depression of IPSPs and (d) single and serial paroxysmal depolarization shifts (PDSs). Serial PDSs were reflected by large synchronous waves in the surface ECoG. © 1979.

引用

页码：745 / 751

页数：7

共 45 条

[1] AJMONEMARSAN C, 1974, HDB CLIN NEUROLOGY, V15, P30
[2] AJMONEMARSAN C, 1969, BASIC MECH EPILEPSIE, P229
[3] GENESIS OF EPILEPTIC INTERICTAL SPIKES - NEW KNOWLEDGE OF CORTICAL FEEDBACK-SYSTEMS SUGGESTS A NEUROPHYSIOLOGICAL EXPLANATION OF BRIEF PAROXYSMS
AYALA, GF
DICHTER, M
GUMNIT, RJ
MATSUMOTO, H
SPENCER, WA
[J]. BRAIN RESEARCH, 1973, 52 (MAR30) : 1 - 17
[4] EXCITABILITY CHANGES AND INHIBITORY MECHANISMS IN NEOCORTICAL NEURONS DURING SEIZURES
AYALA, GF
MATSUMOTO, H
GUMNIT, RJ
[J]. JOURNAL OF NEUROPHYSIOLOGY, 1970, 33 (01) : 73 - +
[5] BARANYI A, 1978, EXP BRAIN RES, V33, P283
[6] CHANELET J, 1969, CR SOC BIOL, V163, P365
[7] COLTON JS, 1976, BIOPHYS J, V16, pA118
[8] PTZ-INDUCED PAROXYSMAL DEPOLARIZATION SHIFT ON HELIX P NEURONS - MECHANISM OF PLATEAU AND PACEMAKER POTENTIALS
DUCREUX, C
GOLA, M
[J]. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1975, 361 (01): : 43 - 53
[9] DUCREUX C, 1978, ABNORMAL NEURONAL DI, P271
[10] GILLESPIE JI, 1975, J PHYSIOL-LONDON, V252, pP70

← 1 2 3 4 5 →