BCL-2 BLOCKS GLUTAMATE TOXICITY IN NEURAL CELL-LINES

被引：98

作者：

ZHONG, LT ^{[1
]}

KANE, DJ ^{[1
]}

BREDESEN, DE ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES, SCH MED, DEPT NEUROL, LOS ANGELES, CA 90024 USA

来源：

MOLECULAR BRAIN RESEARCH | 1993年 / 19卷 / 04期

关键词：

GLUTAMATE TOXICITY; EXCITOTOXICITY; BCL-2; CEREBELLAR NEURON;

D O I：

10.1016/0169-328X(93)90139-G

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Glutamate has been shown, at high concentrations (5-10 mM), to lead to death in cells of the pheochromocytoma cell line PC12. We report that similar concentrations of glutamate also kill immortalized central neural cell lines, and that the expression of the proto-oncogene bcl-2 in these cell lines blocks glutamate neurotoxicity. Potassium chloride (25 mM) also protects a cerebellar neuronal cell line, but not PC12 cells, from glutamate toxicity.

引用

页码：353 / 355

页数：3

共 15 条

[1]

CHAN PH, 1990, STROKE, V21, P80

[2]

GIOTTA GJ, 1982, NEUROSCIENCE APPROAC, V1, P203

[3] ALTERATION OF NEURAL CELL-ADHESION MOLECULE (N-CAM) EXPRESSION AFTER NEURONAL CELL-TRANSFORMATION BY ROUS-SARCOMA VIRUS [J].

GREENBERG, ME ;

BRACKENBURY, R ;

EDELMAN, GM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (03) :969-973

[4] BCL-2 IS AN INNER MITOCHONDRIAL-MEMBRANE PROTEIN THAT BLOCKS PROGRAMMED CELL-DEATH [J].

HOCKENBERY, D ;

NUNEZ, G ;

MILLIMAN, C ;

SCHREIBER, RD ;

KORSMEYER, SJ .

NATURE, 1990, 348 (6299) :334-336

[5] ROLE OF NERVE GROWTH-FACTOR IN OXIDANT-ANTIOXIDANT BALANCE AND NEURONAL INJURY .1. STIMULATION OF HYDROGEN-PEROXIDE RESISTANCE [J].

JACKSON, GR ;

APFFEL, L ;

WERRBACHPEREZ, K ;

PEREZPOLO, JR .

JOURNAL OF NEUROSCIENCE RESEARCH, 1990, 25 (03) :360-368

[6] ROLE OF NERVE GROWTH-FACTOR IN OXIDANT-ANTIOXIDANT BALANCE AND NEURONAL INJURY .2. A CONDITIONING LESION PARADIGM [J].

JACKSON, GR ;

WERRBACHPEREZ, K ;

PEREZPOLO, JR .

JOURNAL OF NEUROSCIENCE RESEARCH, 1990, 25 (03) :369-374

[7] THE PROTOONCOGENE BCL-2 INHIBITS APOPTOSIS IN PC12 CELLS [J].

MAH, SP ;

ZHONG, LT ;

LIU, Y ;

ROGHANI, A ;

EDWARDS, RH ;

BREDESEN, DE .

JOURNAL OF NEUROCHEMISTRY, 1993, 60 (03) :1183-1186

[8] HIGH-AFFINITY TRANSPORT OF GLUTATHIONE IS PART OF A MULTICOMPONENT SYSTEM ESSENTIAL FOR MITOCHONDRIAL-FUNCTION [J].

MARTENSSON, J ;

LAI, JCK ;

MEISTER, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (18) :7185-7189

[9]

MELDRUM B, 1991, TRENDS PHARM SCI PHA, P54

[10] IMMORTALIZATION OF HYPOTHALAMIC GNRH NEURONS BY GENETICALLY TARGETED TUMORIGENESIS [J].

MELLON, PL ;

WINDLE, JJ ;

GOLDSMITH, PC ;

PADULA, CA ;

ROBERTS, JL ;

WEINER, RI .

NEURON, 1990, 5 (01) :1-10

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