TISSUE-CULTURE MODEL OF CARTILAGE BREAKDOWN IN RHEUMATOID-ARTHRITIS .3. EFFECTS OF ANTI-RHEUMATIC DRUGS

被引：46

作者：

STEINBERG, J

TSUKAMOTO, S

SLEDGE, CB

机构：

[1] Orthopedic Research Laboratory, Robert B. Brigham Hospital, Boston, Massachusetts

来源：

ARTHRITIS AND RHEUMATISM | 1979年 / 22卷 / 08期

关键词：

D O I：

10.1002/art.1780220811

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effects of hydrocortisone, indomethacin, and gold thiomalate on proteoglycan release were assessed in bovine nasal cartilage‐rheumatoid synovium cocultures. Of the three agents, only hydrocortisone consistently inhibited both basal and synovium‐stimulated cartilage breakdown. Hydrocortisone responsivity was a direct function of the degradative capacity of synovial specimens, and this was equally well demonstrated both in patients receiving long‐term therapy and those given perioperative glucocorticoid therapy. The data are consistent with significant hydrocortisone inhibition of lysosomal enzyme‐mediated degradation of cartilage. Copyright © 1979 American College of Rheumatology

引用

页码：877 / 885

页数：9

共 22 条

[1] AARON R, UNPUBLISHED
[2] BARRETT AJ, 1975, DYNAMICS CONNECTIVE, P189
[3] EHRLICH GE, 1977, RHEUMATIC DISEASES, P897
[4] NEW ASPECTS OF MODE OF ACTION OF NONSTEROID ANTIINFLAMMATORY DRUGS
FERREIRA, SH
VANE, JR
[J]. ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1974, 14 : 57 - 73
[5] FURST D, 1976, ARTHRITIS RHEUM, V19, P796
[6] ULTRASTRUCTURAL CHANGES PRODUCED IN RHEUMATOID SYNOVIAL-MEMBRANE BY CHRYSOTHERAPY
GHADIALLY, FN
ORYSCHAK, AF
MITCHELL, DM
[J]. ANNALS OF THE RHEUMATIC DISEASES, 1976, 35 (01) : 67 - 72
[7] TISSUE GOLD CONCENTRATION IN A RHEUMATOID ARTHRITIC RECEIVING CHRYSOTHERAPY
GOTTLIEB, NL
SMITH, EM
SMITH, PM
[J]. ARTHRITIS AND RHEUMATISM, 1972, 15 (01): : 16 - +
[8] PHARMACODYNAMICS OF AU-197 AND AU-195 LABELED AUROTHIOMALATE IN BLOOD - CORRELATION WITH COURSE OF RHEUMATOID-ARTHRITIS, GOLD TOXICITY AND GOLD EXCRETION
GOTTLIEB, NL
SMITH, PM
SMITH, EM
[J]. ARTHRITIS AND RHEUMATISM, 1974, 17 (02): : 171 - 188
[9] STUDIES ON PATHOGENESIS OF RHEUMATOID JOINT INFLAMMATION .I. RA CELL AND A WORKING HYPOTHESIS
HOLLANDER, JL
MCCARTY, DJ
ASTORGA, G
CASTROMU.E
[J]. ANNALS OF INTERNAL MEDICINE, 1965, 62 (02) : 271 - +
[10] EFFECTS OF CERTAIN ANTIRHEUMATIC DRUGS ON NORMAL HUMAN PERIPHERAL-BLOOD LYMPHOCYTES - INHIBITION OF MITOGEN-STIMULATED AND ANTIGEN-STIMULATED INCORPORATION OF TRITIATED-THYMIDINE
PANUSH, RS
[J]. ARTHRITIS AND RHEUMATISM, 1976, 19 (05): : 907 - 917

← 1 2 3 →