TISSUE-CULTURE MODEL OF CARTILAGE BREAKDOWN IN RHEUMATOID-ARTHRITIS .3. EFFECTS OF ANTI-RHEUMATIC DRUGS

被引：46

作者：

STEINBERG, J

TSUKAMOTO, S

SLEDGE, CB

机构：

[1] Orthopedic Research Laboratory, Robert B. Brigham Hospital, Boston, Massachusetts

来源：

ARTHRITIS AND RHEUMATISM | 1979年 / 22卷 / 08期

关键词：

D O I：

10.1002/art.1780220811

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effects of hydrocortisone, indomethacin, and gold thiomalate on proteoglycan release were assessed in bovine nasal cartilage‐rheumatoid synovium cocultures. Of the three agents, only hydrocortisone consistently inhibited both basal and synovium‐stimulated cartilage breakdown. Hydrocortisone responsivity was a direct function of the degradative capacity of synovial specimens, and this was equally well demonstrated both in patients receiving long‐term therapy and those given perioperative glucocorticoid therapy. The data are consistent with significant hydrocortisone inhibition of lysosomal enzyme‐mediated degradation of cartilage. Copyright © 1979 American College of Rheumatology

引用

页码：877 / 885

页数：9

共 22 条

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