GENES ENCODING GENERAL INITIATION-FACTORS FOR RNA-POLYMERASE-II TRANSCRIPTION ARE DISPERSED IN THE HUMAN GENOME

被引:32
作者
HENG, HHQ
XIAO, H
SHI, XM
GREENBLATT, J
TSUI, LC
机构
[1] UNIV TORONTO,DEPT MOLEC & MED GENET,TORONTO M5G 1X8,ON,CANADA
[2] HOSP SICK CHILDREN,RES INST,DEPT GENET,TORONTO M5G 1X8,ON,CANADA
[3] UNIV TORONTO,BANTING & BEST DEPT MED RES,TORONTO M5G 1L6,ON,CANADA
基金
英国医学研究理事会;
关键词
D O I
10.1093/hmg/3.1.61
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
General transcription factors are required for accurate initiation of transcription by RNA polymerase II. Human cDNAs encoding subunits of these factors have been cloned and sequenced. Using fluorescence in situ hybridization (FISH), we show here that the genes encoding the TATA-box binding protein (TBP), TFIIB, TFIIE alpha, TFIIE beta, RAP30, RAP74 and the 62 kDa subunit of TFIIH are located at the human chromosomal bands 6q26 - 27, 1p21 - 22, 3q21 - 24, 8p12, 13q14, 19p13.3 and 11p14 - 15.1, respectively. This dispersed localization of a group of functionally related gene provides insights into the molecular mechanism of human genome evolution and their possible involvement in human diseases.
引用
收藏
页码:61 / 64
页数:4
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