TRANSCRIPTION FACTORS, TRANSLOCATIONS AND HEMATOLOGICAL MALIGNANCIES

被引：13

作者：

GREEN, AR

机构：

[1] University of Cambridge Dept of Haematology, MRC Centre, Cambridge, CB2 2QH, Hills Road

来源：

BLOOD REVIEWS | 1992年 / 6卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/0268-960X(92)90013-G

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Haematological malignancies arise as a consequence of clonal evolution driven by an accumulation of somatic mutations. Many haematological malignancies are associated with chromosome translocations that have provided powerful tools for the identification of proto-oncogenes implicated in the pathogenesis of leukaemia/lymphoma. The recent characterisation of several translocation breakpoints associated with human haematological tumours has demonstrated that genes encoding transcription factors are frequently involved. Direct alteration of transcription factor activity by somatic mutation may represent a particularly powerful leukaemogenic event.

引用

收藏

页码：118 / 124

页数：7

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