KINETICS AND THERMODYNAMICS OF THE INTERACTION OF 5-FLUORO-2'-DEOXYURIDYLATE WITH THYMIDYLATE SYNTHASE

被引:80
作者
SANTI, DV
MCHENRY, CS
RAINES, RT
IVANETICH, KM
机构
[1] UNIV CALIF SAN FRANCISCO, DEPT PHARMACEUT CHEM, SAN FRANCISCO, CA 94143 USA
[2] UNIV CALIF SAN FRANCISCO, HORMONE RES INST, SAN FRANCISCO, CA 94143 USA
[3] UNIV COLORADO, HLTH SCI CTR, DEPT BIOCHEM BIOPHYS & GENET, DENVER, CO 80262 USA
关键词
D O I
10.1021/bi00400a017
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:8606 / 8613
页数:8
相关论文
共 29 条
[1]   ON THE MECHANISM OF ACTION OF FOLATE-REQUIRING AND BIOPTERIN-REQUIRING ENZYMES [J].
BENKOVIC, SJ .
ANNUAL REVIEW OF BIOCHEMISTRY, 1980, 49 :227-251
[2]   SECONDARY ALPHA-HYDROGEN ISOTOPE EFFECTS ON THE INTERACTION OF 5-FLUORO-2'-DEOXYURIDYLATE AND 5,10-METHYLENETETRAHYDROFOLATE WITH THYMIDYLATE SYNTHETASE [J].
BRUICE, TW ;
SANTI, DV .
BIOCHEMISTRY, 1982, 21 (26) :6703-6709
[3]  
Cleland W W, 1980, Methods Enzymol, V64, P104
[4]  
CRUSBERG TC, 1970, J BIOL CHEM, V245, P5292
[5]  
DANENBERG KD, 1979, J BIOL CHEM, V254, P4345
[6]   EFFECT OF 5,10-METHYLENETETRAHYDROFOLATE ON DISSOCIATION OF 5-FLUORO-2'-DEOXYURIDYLATE FROM THYMIDYLATE SYNTHETASE - EVIDENCE FOR AN ORDERED MECHANISM [J].
DANENBERG, PV ;
DANENBERG, KD .
BIOCHEMISTRY, 1978, 17 (19) :4018-4024
[7]   ANATOMY OF AN SN1 REACTION - CRYSTAL-STRUCTURE REACTIVITY CORRELATIONS FOR 1-ARYLETHANOL DERIVATIVES [J].
EDWARDS, MR ;
JONES, PG ;
KIRBY, AJ .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (22) :7067-7073
[8]  
FERSHT A, 1985, ENZYME STRUCTURE MEC, P311
[10]   RESONANCE RAMAN-SPECTROSCOPIC EVIDENCE FOR ALTERNATIVE STRUCTURES IN THE NATIVE TERNARY COMPLEX FORMED WITH THYMIDYLATE SYNTHASE [J].
FITZHUGH, AL ;
FODOR, S ;
KAUFMAN, S ;
SPIRO, TG .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (23) :7422-7424