REGULATION OF ACETYLCHOLINE-RECEPTOR GENE-EXPRESSION IN RATS TREATED WITH ALPHA-BUNGAROTOXIN

被引：15

作者：

ASHER, O ^{[1
]}

PROVENZANO, C ^{[1
]}

FUCHS, S ^{[1
]}

机构：

[1] WEIZMANN INST SCI, DEPT CHEM IMMUNOL, IL-76100 REHOVOT, ISRAEL

来源：

FEBS LETTERS | 1991年 / 282卷 / 02期

关键词：

ALPHA-BUNGAROTOXIN; ACETYLCHOLINE RECEPTOR TRANSCRIPT; EXPERIMENTAL AUTOIMMUNE MYASTHENIA GRAVIS; DENERVATION; MYOGENIN; MYOD1;

D O I：

10.1016/0014-5793(91)80487-N

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Regulation of acetylcholine receptor (AChR) gene expression was analyzed in alpha-bungarotoxin (alpha-BTX) treated rats. A reduction in available I-125-alpha-BTX binding sites was accompanied by an increase in the various AChR transcripts. The increase in the AChR alpha-, beta- epsilon- and delta-subunit mRNAs was similar to that observed in rats with experimental autoimmune myasthenia gravis (EAMG). Unlike in EAMG, the gamma-subunit transcripts reappeared following alpha-BTX treatment. The quantitative differences in the levels of AChR transcripts between alpha-BTX treatment and EAMG on one hand and denervation on the other hand, support the notion that the regulation of AChR gene expression is controlled by muscle activity and by neuronal factors as well. We also demonstrate in this report that myogenin transcripts increase following alpha-BTX treatment as well as following denervation, whereas MyoD1 transcripts remain stable.

引用

页码：242 / 246

页数：5

共 21 条

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