ACTIVATION OF MITOMYCIN-C AND QUINONE DRUG-METABOLISM BY NADPH-CYTOCHROME-P-450 REDUCTASE

被引：42

作者：

KOMIYAMA, T ^{[1
]}

OKI, T ^{[1
]}

INUI, T ^{[1
]}

机构：

[1] SANRAKU OCEAN CO LTD,CENT RES LABS,FUJISAWA 251,JAPAN

来源：

JOURNAL OF PHARMACOBIO-DYNAMICS | 1979年 / 2卷 / 06期

关键词：

antitumor quinone drugs; drug metabolism; mitomycin C; NADPH-cytochrome P-450 reductase; xanthine oxidase;

D O I：

10.1248/bpb1978.2.407

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Microsomal NADPH-cytochrome P-450 reductase (EC 1.6.2.4) and xanthine oxidase (EC 1.2.3.2) catalyzed the activation of antitumor antibiotic, mitomycin C, under anaerobic conditions. Under aerobic conditions, NADPH-cytochrome P-450 reductase catalyzed the quinone structure containing antitumor compound-dependent NADPH oxidation. With our previous results, the direct contribution of NADPH-cytochrome P-450 reductase to the quinone drug metabolism was generalized. © 1979, The Pharmaceutical Society of Japan. All rights reserved.

引用

页码：407 / 410

页数：4

共 24 条

[1] NADPH CYTOCHROME-P-450 REDUCTASE ACTIVATION OF QUINONE ANTI-CANCER AGENTS TO FREE-RADICALS [J].

BACHUR, NR ;

GORDON, SL ;

GEE, MV ;

KON, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (02) :954-957

[2]

BACHUR NR, 1978, CANCER RES, V38, P1745

[3] GENERATION OF FREE-RADICALS AND LIPID PEROXIDATION BY REDOX CYCLING OF ADRIAMYCIN AND DAUNOMYCIN [J].

GOODMAN, J ;

HOCHSTEIN, P .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1977, 77 (02) :797-803

[4]

HANDA K, 1976, GANN, V67, P523

[5]

HATA T, 1956, J ANTIBIOT, V9, P141

[6] ONE-ELECTRON-TRANSFER REACTIONS IN BIOCHEMICAL SYSTEMS .3. ONE-ELECTRON REDUCTION OF QUINONES BY MICROSOMAL FLAVIN ENZYMES [J].

IYANAGI, T ;

YAMAZAKI, I .

BIOCHIMICA ET BIOPHYSICA ACTA, 1969, 172 (03) :370-&

[7] MITOMYCINS + PORFIROMYCIN - CHEMICAL MECHANISM OF ACTIVATION + CROSS-LINKING OF DNA [J].

IYER, VN ;

SZYBALSKI, W .

SCIENCE, 1964, 145 (362) :55-&

[8] NADH-DEPENDENT CINERULOSE REDUCTASE IN RAT-LIVER MICROSOMES [J].

KOMIYAMA, T ;

OKI, T ;

INUI, T ;

TAKEUCHI, T ;

UMEZAWA, H .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1978, 82 (01) :188-195

[9]

KOMIYAMA T, 1979, GANN, V70, P403

[10]

LOWRY OH, 1951, J BIOL CHEM, V193, P265

← 1 2 3 →