ACTIVATION OF MITOMYCIN-C AND QUINONE DRUG-METABOLISM BY NADPH-CYTOCHROME-P-450 REDUCTASE

被引：42

作者：

KOMIYAMA, T ^{[1
]}

OKI, T ^{[1
]}

INUI, T ^{[1
]}

机构：

[1] SANRAKU OCEAN CO LTD,CENT RES LABS,FUJISAWA 251,JAPAN

来源：

JOURNAL OF PHARMACOBIO-DYNAMICS | 1979年 / 2卷 / 06期

关键词：

antitumor quinone drugs; drug metabolism; mitomycin C; NADPH-cytochrome P-450 reductase; xanthine oxidase;

D O I：

10.1248/bpb1978.2.407

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Microsomal NADPH-cytochrome P-450 reductase (EC 1.6.2.4) and xanthine oxidase (EC 1.2.3.2) catalyzed the activation of antitumor antibiotic, mitomycin C, under anaerobic conditions. Under aerobic conditions, NADPH-cytochrome P-450 reductase catalyzed the quinone structure containing antitumor compound-dependent NADPH oxidation. With our previous results, the direct contribution of NADPH-cytochrome P-450 reductase to the quinone drug metabolism was generalized. © 1979, The Pharmaceutical Society of Japan. All rights reserved.

引用

页码：407 / 410

页数：4

共 24 条

[11] BIOACTIVATION AS A MODEL FOR DRUG DESIGN BIOREDUCTIVE ALKYLATION [J].

MOORE, HW .

SCIENCE, 1977, 197 (4303) :527-532

[12] MECHANISM OF REDUCTION OF CYTOCHROME C BY XANTHINE OXIDASE [J].

MURAOKA, S ;

ENOMOTO, H ;

SUGIYAMA, M ;

YAMASAKI, H .

BIOCHIMICA ET BIOPHYSICA ACTA, 1967, 143 (02) :408-&

[13] ONE-ELECTRON TRANSFER REACTIONS IN BIOCHEMICAL SYSTEMS .4. A MIXED MECHANISM IN REACTION OF MILK XANTHINE OXIDASE WITH ELECTRON ACCEPTORS [J].

NAKAMURA, S ;

YAMAZAKI, I .

BIOCHIMICA ET BIOPHYSICA ACTA, 1969, 189 (01) :29-&

[14]

NAKAO H, 1972, CHEM PHARM BULL, V20, P1968

[15] VITAMIN-K3-DEPENDENT NADPH OXIDASE OF LIVER MICROSOMES - PURIFICATION, PROPERTIES, AND IDENTITY WITH MICROSOMAL NADPH-CYTOCHROME-C REDUCTASE [J].

NISHIBAY.H ;

SATO, R .

JOURNAL OF BIOCHEMISTRY, 1970, 67 (02) :199-&

[16] REDUCTIVE CLEAVAGE OF ANTHRACYCLINE GLYCOSIDES BY MICROSOMAL NADPH-CYTOCHROME-C REDUCTASE [J].

OKI, T ;

KOMIYAMA, T ;

TONE, H ;

INUI, T ;

TAKEUCHI, T ;

UMEZAWA, H .

JOURNAL OF ANTIBIOTICS, 1977, 30 (07) :613-615

[17] NEW ANTITUMOR ANTIBIOTICS, ACLACINOMYCIN-A AND ACLACINOMYCIN-B [J].

OKI, T ;

MATSUZAWA, Y ;

YOSHIMOTO, A ;

NUMATA, K ;

KITAMURA, I ;

HORI, S ;

TAKAMATSU, A ;

UMEZAWA, H ;

ISHIZUKA, M ;

NAGANAWA, H ;

SUDA, H ;

HAMADA, M ;

TAKEUCHI, T .

JOURNAL OF ANTIBIOTICS, 1975, 28 (10) :830-834

[18] A NEW METHOD FOR SIMULTANEOUS PURIFICATION OF CYTOCHROME-B5 AND NADPH-CYTOCHROME-C REDUCTASE FROM RAT LIVER MICROSOMES [J].

OMURA, T ;

TAKESUE, S .

JOURNAL OF BIOCHEMISTRY, 1970, 67 (02) :249-&

[19] STRUCTURE OF STREPTONIGRIN [J].

RAO, KV ;

BIEMANN, K ;

WOODWARD, RB .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1963, 85 (16) :2532-&

[20]

SATO S, 1977, GANN, V68, P603

← 1 2 3 →