A HUMAN PSEUDOAUTOSOMAL GENE, ADP ATP TRANSLOCASE, ESCAPES X-INACTIVATION WHEREAS A HOMOLOG ON XQ IS SUBJECT TO X-INACTIVATION

被引：71

作者：

SCHIEBEL, K ^{[1
]}

WEISS, B ^{[1
]}

WOHRLE, D ^{[1
]}

RAPPOLD, G ^{[1
]}

机构：

[1] UNIV ULM,DEPT CLIN GENET,W-7900 ULM,GERMANY

来源：

NATURE GENETICS | 1993年 / 3卷 / 01期

关键词：

D O I：

10.1038/ng0193-82

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We report the cloning of a highly conserved pseudoautosomal gene on the human sex chromosomes. A cDNA clone was selected by crosshybridization with a microdissected clone from the chromosomal subregion Xp22.3. It encodes a previously characterized member of the ADP/ATP translocase family and plays a fundamental role in cellular energy metabolism. This gene, ANT3, is located approximately 1,300 kilobases from the telomere, proximal to the pseudoautosomal gene CSF2RA, and escapes X-inactivation. Interestingly, a homologue of ANT3, ANT2, maps to Xq and is subject to X-inactivation. These genes provide the first evidence of two closely related X-chromosomal genes, which show striking differences in their X-inactivation behaviour.

引用

页码：82 / 87

页数：6

共 53 条

[21] LOCALIZATION OF THE HUMAN GM-CSF RECEPTOR GENE TO THE X-Y PSEUDOAUTOSOMAL REGION [J].