THE DIAGNOSIS OF TOXOPLASMOSIS USING IGG AVIDITY

被引:54
作者
HOLLIMAN, RE
RAYMOND, R
RENTON, N
JOHNSON, JD
机构
[1] PHLS Toxoplasma Reference Unit, St George's Hospital, London SW17 0QT, Blackshaw Road
关键词
D O I
10.1017/S0950268800057812
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Current methods to establish the duration of toxoplasma infection in pregnant women and for the diagnosis of toxoplasmosis in the neonate or HIV infected patient have significant limitations. We assessed the precision of a commercial ELISA for the detection of toxoplasma specific IgG and adapted the assay to measure avidity using an elution agent washing step. The sensitivity and specificity of the ELISA were 100 and 75 % respectively and optimal measurement of avidity was achieved using 6 M urea as the elution agent. Toxoplasma lymphadenopathy of less than 3 months duration was associated with low avidity specific IgG but some discordant findings were recorded. Serial measurement of IgG avidity assisted the distinction between actively produced antibody in infants with congenital toxoplasmosis and passively acquired antibody of maternal origin in uninfected babies. There was no significant difference between avidity levels in HIV infected patients with or without cerebral toxoplasmosis.
引用
收藏
页码:399 / 408
页数:10
相关论文
共 20 条
[1]   STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT [J].
BLAND, JM ;
ALTMAN, DG .
LANCET, 1986, 1 (8476) :307-310
[2]   AVIDITY OF SPECIFIC IGG ANTIBODY AS A MARKER OF RECENT AND OLD TOXOPLASMA INFECTIONS [J].
CAMARGO, ME ;
DASILVA, SM ;
LESER, PG ;
GRANATO, CH .
REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO, 1991, 33 (03) :213-218
[3]  
COOK GC, 1990, Q J MED, V74, P3
[4]  
DESMONTS G, 1990, PRESSE MED, V19, P1445
[5]   ASSESSMENT OF IMMUNOGLOBULIN-M IMMUNOSORBENT AGGLUTINATION ASSAY (ISAGA) FOR DETECTING TOXOPLASMA SPECIFIC IGM [J].
DUFFY, KMT ;
WHARTON, PJ ;
JOHNSON, JD ;
NEW, L ;
HOLLIMAN, RE .
JOURNAL OF CLINICAL PATHOLOGY, 1989, 42 (12) :1291-1295
[6]   SPONTANEOUS-ABORTION AND REINFECTION BY TOXOPLASMA-GONDII [J].
FORTIER, B ;
AISSI, E ;
AJANA, F ;
DIEUSART, P ;
DENIS, P ;
DELASSALLE, EM ;
LECOMTEHOUCKE, M ;
VINATIER, D .
LANCET, 1991, 338 (8764) :444-444
[7]   RECENT PRIMARY TOXOPLASMA INFECTION INDICATED BY A LOW AVIDITY OF SPECIFIC IGG [J].
HEDMAN, K ;
LAPPALAINEN, M ;
SEPPALA, I ;
MAKELA, O .
JOURNAL OF INFECTIOUS DISEASES, 1989, 159 (04) :736-740
[8]   RAPID DIAGNOSIS OF HANTAVIRUS DISEASE WITH AN IGG-AVIDITY ASSAY [J].
HEDMAN, K ;
VAHERI, A ;
BRUMMERKORVENKONTIO, M .
LANCET, 1991, 338 (8779) :1353-1356
[9]   THE POST-NATAL SERODIAGNOSIS OF CONGENITAL TOXOPLASMOSIS [J].
HOLLIMAN, RE ;
JOHNSON, JD .
SERODIAGNOSIS AND IMMUNOTHERAPY IN INFECTIOUS DISEASE, 1989, 3 (05) :323-327
[10]   TOXOPLASMOSIS AND THE ACQUIRED IMMUNE-DEFICIENCY SYNDROME [J].
HOLLIMAN, RE .
JOURNAL OF INFECTION, 1988, 16 (02) :121-128