RETINOIC ACID AND HOMEOBOX GENE-REGULATION

被引：85

作者：

LANGSTON, AW ^{[1
]}

GUDAS, LJ ^{[1
]}

机构：

[1] CORNELL UNIV, COLL MED, DEPT PHARMACOL, NEW YORK, NY 10021 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1994年 / 4卷 / 04期

关键词：

D O I：

10.1016/0959-437X(94)90071-A

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Hox genes have been shown to be important regulators of pattern formation in vertebrates, Retinoic acid has been shown to affect the expression of Hox genes in vitro and in vivo, and some of its effects on development correspond to changes in Hox gene expression. The idea that retinoic acid is not simply a powerful pharmocological agent, but rather that it plays an important role in creating the normal expression patterns of Hox genes, is provided by the recent identification of retinoic acid responsive enhancers near Hox genes.

引用

页码：550 / 555

页数：6

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